The lncARSR/PTEN/Akt/nuclear factor‐kappa B feedback regulatory loop contributes to doxorubicin resistance in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23119
Abstract: Chemoresistance is a major obstacle to hepatocellular carcinoma (HCC) chemotherapy. Our previous study found that long noncoding RNA lncARSR (lncRNA Activated in RCC with Sunitinib Resistance) activated Akt signaling via repressing phosphatase and tensin homolog… read more here.
Keywords: regulatory loop; doxorubicin resistance; resistance; feedback regulatory ... See more keywords
LncRNA MALAT1 promotes breast cancer progression and doxorubicin resistance via regulating miR-570–3p
Sign Up to like & getrecommendations! Published in 2020 at "Biomedical journal"
DOI: 10.1016/j.bj.2020.11.002
Abstract: Abstract Background Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) that regulates disease progression in various types of cancers. The aim of this study was to explore the role of MALAT1… read more here.
Keywords: doxorubicin resistance; mir 570; progression doxorubicin; malat1 ... See more keywords
Reversal of epigenetic aberrations associated with the acquisition of doxorubicin resistance restores drug sensitivity in breast cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.07.028
Abstract: ABSTRACT Acquired resistance against doxorubicin is a major limitation in clinical treatment of breast cancer. The molecular mechanism behind the aberrant expression of genes leading to doxorubicin resistance is not clear. Epigenetic changes play an… read more here.
Keywords: doxorubicin resistance; resistance; cancer cells; breast cancer ... See more keywords
LncRNA FENDRR sensitizes doxorubicin-resistance of osteosarcoma cells through down-regulating ABCB1 and ABCC1.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17985
Abstract: Long noncoding RNAs (LncRNAs) act as crucial regulators in various cancers including osteosarcoma (OS), yet their potential roles and molecular mechanisms in OS chemoresistance remain unclear. In the present study, we investigated the role and… read more here.
Keywords: doxorubicin resistance; abcb1 abcc1; osteosarcoma; lncrna fendrr ... See more keywords
DUSP4 promotes doxorubicin resistance in gastric cancer through epithelial-mesenchymal transition
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DOI: 10.18632/oncotarget.21522
Abstract: Chemoresistance limits treatment efficacy in gastric cancer and doxorubicin resistance is common in gastric cancer cells. Dual specificity phosphatase 4 (DUSP4) has been associated with tumor progression. This study aimed to investigate the mechanism of… read more here.
Keywords: doxorubicin resistance; dusp4; gastric cancer; cancer cells ... See more keywords
Exosomal Transfer of Macrophage-Derived miR-223 Confers Doxorubicin Resistance in Gastric Cancer
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s283542
Abstract: Purpose Macrophages are a major component of the tumour microenvironment and play an important role in chemoresistance of cancer. However, how exosomal microRNAs (miRNAs) derived from macrophages contribute to the development of doxorubicin resistance in… read more here.
Keywords: mir 223; cancer; macrophage derived; resistance ... See more keywords
Exosomal CircPRRX1 Enhances Doxorubicin Resistance in Gastric Cancer by Regulating MiR-3064-5p/PTPN14 Signaling
Sign Up to like & getrecommendations! Published in 2020 at "Yonsei Medical Journal"
DOI: 10.3349/ymj.2020.61.9.750
Abstract: Purpose Gastric cancer (GC) is a malignant tumor with a high mortality rate. Drug resistance is a major obstacle to GC therapy. This study aimed to investigate the role and mechanism of exosomal circPRRX1 in… read more here.
Keywords: doxorubicin resistance; 3064 ptpn14; resistance; mir 3064 ... See more keywords
Exploring a four-gene risk model based on doxorubicin resistance-associated lncRNAs in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1015842
Abstract: Background: Liver cancer is a lethal cancer type among which hepatocellular carcinoma (HCC) is the most common manifestation globally. Drug resistance is a central problem impeding the efficiency of HCC treatment. Long non-coding RNAs reportedly… read more here.
Keywords: doxorubicin resistance; risk model; risk; resistance ... See more keywords
MDR1 Inhibition Reverses Doxorubicin-Resistance in Six Doxorubicin-Resistant Canine Prostate and Bladder Cancer Cell Lines
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098136
Abstract: Acquired chemoresistance during chemotherapy, often accompanied by cross- and multi-resistance, limits therapeutic outcomes and leads to recurrence. In order to create in vitro model systems to understand acquired doxorubicin-resistance, we generated doxorubicin-resistant sublines of canine… read more here.
Keywords: cell; doxorubicin resistance; resistance; cell lines ... See more keywords
Transfer of exosomal microRNAs confers doxorubicin resistance in osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2023.12973
Abstract: Osteosarcoma (OS) is the commonest primary malignant bone tumor in children and adolescents. However, chemotherapy resistance is a major challenge for the treatment of OS. Exosomes have been reported to serve an increasingly important role… read more here.
Keywords: cells mg63; doxorubicin resistance; osteosarcoma; transfer exosomal ... See more keywords