Synthesis and Characterization of Photoactivatable Doxycycline Analogues Bearing Two‐Photon‐Sensitive Photoremovable Groups Suitable for Light‐Induced Gene Expression
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201700628
Abstract: We report the synthesis and photolytic properties of caged 9‐aminodoxycycline derivatives modified with 2‐{4′‐bis‐[2‐(2methoxyethoxy)ethyl]‐4‐nitrobiphenyl‐3‐yl}prop‐1‐oxy (EANBP) and PEG7‐ylated (7‐diethylamino‐2‐oxo‐2H‐chromen‐4‐yl)methyl (PEG7‐DEACM) groups. 9‐Aminodoxycycline is a tetracycline analogue capable of activating transcription through the inducible TetOn transgene expression… read more here.
Keywords: photon sensitive; photon; two photon; light induced ... See more keywords
Novel Biosynthesis of Copper Nanoparticles Using Zingiber and Allium sp. with Synergic Effect of Doxycycline for Anticancer and Bactericidal Activity
Sign Up to like & getrecommendations! Published in 2020 at "Current Microbiology"
DOI: 10.1007/s00284-020-02058-4
Abstract: Copper nanoparticles (CuNPs), due to their cost-effective synthesis, interesting properties, and a wide range of applications in conductive inks, cooling fluids, biomedical field, and catalysis, have attracted the attention of scientific community in recent years.… read more here.
Keywords: cunps; copper nanoparticles; anticancer; synthesis ... See more keywords
Optimized Doxycycline-Inducible Gene Expression System for Genetic Programming of Tumor-Targeting Bacteria
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-021-01624-x
Abstract: In the programming of tumor-targeting bacteria, various therapeutic or reporter genes are expressed by different gene-triggering strategies. Previously, we engineered pJL87 plasmid with an inducible bacterial drug delivery system that simultaneously co-expressed two genes for… read more here.
Keywords: doxycycline; system; expression; promoter ... See more keywords
The cre-inducer doxycycline lowers cytokine and chemokine transcript levels in the gut of mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Applied Genetics"
DOI: 10.1007/s13353-017-0401-x
Abstract: The antibiotic doxycycline is used as an inducer of recombinase (cre)-based conditional gene knockout in mice, which is a common tool to show the effect of disrupted gene functions only in one period of a… read more here.
Keywords: inducer doxycycline; cre inducer; transcript levels; gene ... See more keywords
Doxycycline desensitization in chronic Q fever—A critical tool for the clinician
Sign Up to like & getrecommendations! Published in 2018 at "IDCases"
DOI: 10.1016/j.idcr.2018.01.006
Abstract: We present the case of a 45 year old woman with acute Q fever pneumonia who progressed to the chronic phase of the disease despite azithromycin therapy. A trial of doxycycline was halted because of severe… read more here.
Keywords: desensitization chronic; fever critical; doxycycline; desensitization ... See more keywords
Suppressive antibiotic therapy with oral doxycycline for Staphylococcus aureus prosthetic joint infection: a retrospective study of 39 patients.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2017.04.019
Abstract: The aim of this study was to describe the use of oral doxycycline as suppressive antibiotic therapy (SAT) in patients with Staphylococcus aureus periprosthetic (hip or knee) joint infections. The medical charts of all patients… read more here.
Keywords: staphylococcus aureus; suppressive antibiotic; oral doxycycline; study ... See more keywords
Adaptive resistance evolution of V. cholerae to doxycycline associated with spontaneous mutation.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2020.106097
Abstract: Cholera caused by the Gram negative bacterium Vibrio cholerae has been a serious threat in under developed countries. Though rehydration therapy has been the mainstay of the disease management, antibiotics are also being used as… read more here.
Keywords: evolution cholerae; adaptive resistance; resistance; resistance evolution ... See more keywords
Controlled release of Doxycycline from gum acacia/poly(sodium acrylate) microparticles for oral drug delivery.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.06.108
Abstract: In the present work, Doxycycline loaded gum acacia (GA)/poly(sodium acrylate) (SA) hydrogels were prepared for the oral drug delivery of model drug Doxycycline. The hydrogels were characterized by X-ray diffraction analysis (XRD), Fourier transform infrared… read more here.
Keywords: acacia poly; drug; model; doxycycline ... See more keywords
A solid doxycycline HP-β-CD formulation for reconstitution (i.v. bolus) prepared by scaled-up electrospinning.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119539
Abstract: In this study a new intravenous (i.v.) bolus dosage form of doxycycline was prepared by electrospinning. A tetracycline-type antibiotic with low water solubility (doxycycline (DOX)) was used with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) as solubilizer. The new solid… read more here.
Keywords: formulation; formulation reconstitution; dox; doxycycline ... See more keywords
Physicochemical properties, metalloproteinases inhibition, and antibiofilm activity of doxycycline-doped dental adhesive.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of dentistry"
DOI: 10.1016/j.jdent.2020.103550
Abstract: OBJECTIVES To evaluate the incorporation of doxycycline (DOX) into a commercial dental adhesive regarding physicochemical properties, microtensile bond strength (μTBS), nanoleakage (NL), nanohardness (NH) and Young's modulus (YM), metalloproteinases (MMP) inhibition, and antibiofilm activity. METHODS… read more here.
Keywords: dental adhesive; inhibition; dox; activity ... See more keywords
Biotransformation of doxycycline by Brevundimonas naejangsanensis and Sphingobacterium mizutaii strains.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.125126
Abstract: The fate of doxycycline (DC), a second generation tetracycline antibiotic, in the environment has drawn increasing attention in recent years due to its wide usage. Little is known about the biodegradability of DC in the… read more here.
Keywords: sphingobacterium mizutaii; brevundimonas naejangsanensis; biotransformation; doxycycline ... See more keywords