Dual Role of Glutathione as a Reducing Agent and Cu-Ligand Governs the ROS Production by Anticancer Cu-Thiosemicarbazone Complexes
Sign Up to like & getrecommendations! Published in 2023 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.2c04392
Abstract: α-Pyridyl thiosemicarbazones (TSC) such as Triapine (3AP) and Dp44mT are a promising class of anticancer agents. Contrary to Triapine, Dp44mT showed a pronounced synergism with CuII, which may be due to the generation of reactive… read more here.
Keywords: cuii; ros production; dp44mt; glutathione ... See more keywords
Design and application of a non-toxic platinum derivative of the metal chelator Dp44mT for use as a long-term stable lysosome tracker.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d5cc01596k
Abstract: The thiosemicarbazone Dp44mT and its Pt complex were conjugated to coumarin-based fluorophores. These conjugates proved to be versatile lysosome tracking agents. Specifically, Pt complex 5 remained trapped and produced reliable fluorescence emission in the lysosomes… read more here.
Keywords: dp44mt; non toxic; lysosome tracker; design application ... See more keywords
Abstract B143: The formation of redox active complexes is important for the induction of the UPR by Dp44mT
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-b143
Abstract: Activation of the unfolded protein response (UPR) has been demonstrated in several cancer types. This has been attributed to two main factors, namely: (1) intrinsic factors (e.g., hyperactivation of oncogenes) and (2) extrinsic factors (i.e.,… read more here.
Keywords: formation redox; active complexes; formation; redox active ... See more keywords