Positron emission tomography with [18 F]-DPA-714 unveils a smoldering component in most multiple sclerosis lesions which drives disease progression.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of neurology"
DOI: 10.1002/ana.26657
Abstract: OBJECTIVE To determine the prognostic value of persisting neuroinflammation in multiple sclerosis (MS) lesions, we developed a 18kDa-translocator-protein-PET based classification of each lesion according to innate immune cell content and localization, and assessed the respective… read more here.
Keywords: dpa 714; multiple sclerosis; sclerosis lesions; progression ... See more keywords
Visualization of translocator protein (18 kDa) (TSPO) in the retina of diabetic retinopathy rats using fluorine-18-DPA-714
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Nuclear Medicine"
DOI: 10.1007/s12149-020-01495-2
Abstract: Objectives To investigate the feasibility of a noninvasive method for imaging translocator protein (18 kDa) (TSPO) in the retina of diabetic retinopathy (DR) rats using fluorine-18-DPA-714 ([ 18 F]-DPA-714) micro-positron emission tomography (PET)/X-ray computed tomography (CT).… read more here.
Keywords: translocator protein; dpa 714; retina; tspo retina ... See more keywords
Risk factors of coronary artery disease in rheumatoid arthritis estimated on the basis of the three-year observation.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.06.382
Abstract: s / Atherosclerosis 263 (2017) e111ee282 e118 Aim: After myocardial infarction (MI), patients face a substantial risk of re-infarction. We hypothesize that MI promotes a systemic inflammatory response by inducing increased leukocyte supply from bone… read more here.
Keywords: acute phase; risk; 18f dpa; inflammatory response ... See more keywords
Short-Term Colony-Stimulating Factor 1 Receptor Inhibition–Induced Repopulation After Stroke Assessed by Longitudinal 18F-DPA-714 PET Imaging
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Nuclear Medicine"
DOI: 10.2967/jnumed.121.263004
Abstract: Visual Abstract Studies on colony-stimulating factor 1 receptor (CSF-1R) inhibition–induced microglia depletion indicated that inhibitor withdrawal allowed the renewal of the microglia compartment via repopulation and resolved the inflammatory imbalance. Therefore, we investigated for the… read more here.
Keywords: dpa 714; inhibition; repopulation; 18f dpa ... See more keywords
Molecular Imaging of Immune Cell Dynamics During De- and Remyelination in the Cuprizone Model of Multiple Sclerosis by [18F]DPA-714 PET and MRI
Sign Up to like & getrecommendations! Published in 2019 at "Theranostics"
DOI: 10.7150/thno.32461
Abstract: Background: Activation and dysregulation of innate, adaptive and resident immune cells in response to damage determine the pathophysiology of demyelinating disorders. Among the plethora of involved cells, microglia/macrophages and astrocytes play an important role in… read more here.
Keywords: dpa 714; 18f dpa; 714 pet; model ... See more keywords