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   Articles with "dpcs" as a keyword



DNA-protein cross-links: Formidable challenges to maintaining genome integrity.

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recommendations! Published in 2018 at "DNA repair"

DOI: 10.1016/j.dnarep.2018.08.024

Abstract: DNA is associated with proteins that are involved in its folding and transaction processes. When cells are exposed to chemical cross-linking agents or free radical-generating ionizing radiation, DNA-associated proteins are covalently trapped within the DNA… read more here.

Keywords: cross links; dpcs; dna; protein cross ... See more keywords

Steric stabilization of phycobiliprotein loaded liposome through polyethylene glycol adsorbed cellulose nanocrystals and their impact on the gastrointestinal tract

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recommendations! Published in 2020 at "Food Hydrocolloids"

DOI: 10.1016/j.foodhyd.2019.105252

Abstract: Abstract The goal of the study was to encapsulate phycobiliprotein (PBP), a seaweed bioactive compound with the help of liposome and stabilized through polyethylene glycol adsorbed cellulose nanocrystals (CNC). The study investigated the stability of… read more here.

Keywords: dpcs; polyethylene; glycol adsorbed; polyethylene glycol ... See more keywords

Biological properties of modified bioactive glass on dental pulp cells.

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recommendations! Published in 2019 at "Journal of dentistry"

DOI: 10.1016/j.jdent.2019.01.017

Abstract: Dental caries is a bacteria-caused condition classified among the most common chronic diseases worldwide. Treatment of dental caries implies the use of materials having regenerative and anti-bacterial properties, and controlling inflammation is critical for successful… read more here.

Keywords: bioactive glass; dpcs; pulp cells; dental pulp ... See more keywords

SPRTN and TDP1/TDP2 Independently Suppress 5-Aza-2'-deoxycytidine-Induced Genomic Instability in Human TK6 Cell Line.

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recommendations! Published in 2022 at "Chemical research in toxicology"

DOI: 10.1021/acs.chemrestox.2c00213

Abstract: DNA-protein cross-links (DPCs) are generated by internal factors such as cellular aldehydes that are generated during normal metabolism and external factors such as environmental mutagens. A nucleoside analog, 5-aza-2'-deoxycytidine (5-azadC), is randomly incorporated into the… read more here.

Keywords: tdp1 tdp2; tk6; dpcs; dnmt1 dpcs ... See more keywords

DNA-protein cross-links emerge as major contributors to chemotherapeutic cytotoxicity at physiological equitoxic doses

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-06705-3

Abstract: Chemotherapeutic drugs induce DNA damage, including double-strand breaks (DSBs), interstrand cross-links (ICLs), and DNA-protein cross-links (DPCs), to inhibit cancer cell proliferation. Understanding the relative contributions of these damages is essential for optimizing therapeutic strategies. To… read more here.

Keywords: chemotherapeutic cytotoxicity; protein cross; dna protein; cross links ... See more keywords