Joint Belgian recommendation on screening for DPD-deficiency in patients treated with 5-FU, capecitabine (and tegafur).
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DOI: 10.1080/17843286.2020.1870855
Abstract: Objectives: Fluoropyrimidines such as 5-Fluorouracil (5-FU), capecitabine and tegafur are drugs that are often used in the treatment of maliginancies. The enzyme dihydropyrimidine dehydrogenase (DPD) is the first and rate limiting enzyme of 5-FU catabolism.… read more here.
Keywords: dpd deficiency; deficiency; capecitabine tegafur; screening dpd ... See more keywords
Renal impairment and abnormal liver function tests in pre-therapeutic phenotype-based DPD deficiency screening using uracilemia: a comprehensive population-based study in 1138 patients
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DOI: 10.1177/17588359221148536
Abstract: Background: Dihydropyrimidine dehydrogenase (DPD) deficiency screening is a pre-therapeutic standard to prevent severe fluoropyrimidine-related toxicity. Although several screening methods exist, the accuracy of their results remains debatable. In France, the uracilemia measurement is considered the… read more here.
Keywords: dpd deficiency; deficiency screening; pre therapeutic; renal impairment ... See more keywords