The dipeptidyl peptidase‐4 (DPP‐4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice
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DOI: 10.1002/2211-5463.12498
Abstract: To clarify the effects of a dipeptidyl peptidase‐4 (DPP‐4) inhibitor on whole‐body energy metabolism, we treated mice fed a high‐fat diet (HFD) with teneligliptin, a clinically available DPP‐4 inhibitor. Teneligliptin significantly prevented HFD‐induced obesity and… read more here.
Keywords: inhibitor; teneligliptin; obesity; dpp ... See more keywords
Risk of dipeptidyl peptidase‐4 (DPP‐4) inhibitors on site‐specific cancer: A systematic review and meta‐analysis
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DOI: 10.1002/dmrr.3004
Abstract: The long‐term impact of dipeptidyl peptidase‐4 (DPP‐4) inhibition is unknown, and there are concerns about the influence of DPP‐4 inhibition on carcinogenesis of the pancreas and thyroid. As DPP‐4 is a rather unselective enzyme present… read more here.
Keywords: risk; site specific; dpp inhibitors; specific cancer ... See more keywords
Topical administration of DPP-IV inhibitors prevents retinal neurodegeneration in experimental diabetes
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DOI: 10.1007/s00125-017-4388-y
Abstract: Aims/hypothesisThe main aims of the present study were: (1) to assess the expression and content of dipeptidyl peptidase IV (DPP-IV) in human and db/db mouse retinas, and in human vitreous fluid; and (2) to determine… read more here.
Keywords: topical administration; glp; neurodegeneration; dpp ... See more keywords
The DPP-4 inhibitor vildagliptin impacts the gut microbiota and prevents disruption of intestinal homeostasis induced by a Western diet in mice
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DOI: 10.1007/s00125-018-4647-6
Abstract: Aims/hypothesisDipeptidyl peptidase 4 (DPP-4) inhibitors are agents designed to increase the half-life of incretins. Although they are administered orally, little is known about their effects on the gut microbiota and functions, despite the fact that… read more here.
Keywords: vildagliptin; dpp; gut microbiota; mice ... See more keywords
Predicting DPP-IV inhibitors with machine learning approaches
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DOI: 10.1007/s10822-017-0009-6
Abstract: Dipeptidyl peptidase IV (DPP-IV) is a promising Type 2 diabetes mellitus (T2DM) drug target. DPP-IV inhibitors prolong the action of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP), improve glucose homeostasis without weight gain, edema,… read more here.
Keywords: machine learning; dpp inhibitors; learning approaches; dpp ... See more keywords
The healthy living partnerships to prevent diabetes and the diabetes prevention program: a comparison of year 1 and 2 intervention results
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DOI: 10.1007/s13142-016-0447-z
Abstract: A number of research studies have attempted to translate the behavioral lifestyle intervention delivered in the Diabetes Prevention Program (DPP). To compare the active interventions of two trials, Diabetes Prevention Program DPP and Healthy Living… read more here.
Keywords: intervention; diabetes prevention; prevention program; year ... See more keywords
Treatment with a DPP-4 inhibitor at time of hospital admission for COVID-19 is not associated with improved clinical outcomes: data from the COVID-PREDICT cohort study in The Netherlands
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DOI: 10.1007/s40200-021-00833-z
Abstract: Inhibition of dipeptidyl peptidase (DPP-)4 could reduce coronavirus disease 2019 (COVID-19) severity by reducing inflammation and enhancing tissue repair beyond glucose lowering. We aimed to assess this in a prospective cohort study. We studied in… read more here.
Keywords: clinical outcomes; dpp; cohort; covid ... See more keywords
Light-activatable dual prodrug polymer nanoparticle for precise synergistic chemotherapy guided by drug-mediated computed tomography imaging.
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DOI: 10.1016/j.actbio.2019.05.047
Abstract: The synergistic efficacy and clinical application of light-responsive polymeric co-delivery systems are severely restricted by uncontrollable/imprecise drug loading, release, and adverse effects caused by the introduction of additional light-responsive molecules or contrast agents when diagnostic… read more here.
Keywords: synergistic chemotherapy; prodrug polymer; light activatable; drug ... See more keywords
Diabetes Prevention Program Translation in the Veterans Health Administration.
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DOI: 10.1016/j.amepre.2016.11.009
Abstract: INTRODUCTION This clinical demonstration trial compared the effectiveness of the Veterans Affairs Diabetes Prevention Program (VA-DPP) with an evidence-based usual care weight management program (MOVE!®) in the Veterans Health Administration health system. DESIGN Prospective, pragmatic,… read more here.
Keywords: dpp move; diabetes prevention; program; dpp ... See more keywords
Discovery of triazole-based uracil derivatives bearing amide moieties as novel dipeptidyl peptidase-IV inhibitors.
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DOI: 10.1016/j.bioorg.2017.10.010
Abstract: Dipeptidyl peptidase-IV (DPP-4) is a validated target for T2DM treatment. We previously reported a novel series of triazole-based uracil derivatives bearing aliphatic carboxylic acids with potent DPP-4 inhibitory activities in vitro, but these compounds showed… read more here.
Keywords: dpp; based uracil; compound; triazole based ... See more keywords
A low band gap conjugated small molecule based on isoindigo flanked with diketopyrrolopyrrole for efficient organic solar cells
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DOI: 10.1016/j.dyepig.2016.10.042
Abstract: Abstract Herein, we report design and synthesis of DPP-Ii-DPP, a conjugated small molecule (SM) composed of central isoindigo flanked with diketopyrrolopyrrole (DPP), for organic solar cell (OSC) application. The DPP-Ii-DPP exhibited broad and intense absorption… read more here.
Keywords: flanked diketopyrrolopyrrole; small molecule; isoindigo flanked; conjugated small ... See more keywords