Livedoid and Purpuric Skin Eruptions Associated With Coagulopathy in Severe COVID-19.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2020.2800
Abstract: Importance Despite several recent reports on the elevated risk of bullous pemphigoid in patients with type 2 diabetes treated with dipeptidyl peptidase–4 (DPP-4) inhibitors, evidence on the absolute risk and comparative safety against other antidiabetics… read more here.
Keywords: dpp inhibitor; dpp inhibitors; bullous pemphigoid;
Risk of dipeptidyl peptidase‐4 (DPP‐4) inhibitors on site‐specific cancer: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3004
Abstract: The long‐term impact of dipeptidyl peptidase‐4 (DPP‐4) inhibition is unknown, and there are concerns about the influence of DPP‐4 inhibition on carcinogenesis of the pancreas and thyroid. As DPP‐4 is a rather unselective enzyme present… read more here.
Keywords: risk; site specific; dpp inhibitors; specific cancer ... See more keywords
Dipeptidyl peptidase-4 inhibitors and the risks of autoimmune diseases in type 2 diabetes mellitus patients in Taiwan: a nationwide population-based cohort study
Sign Up to like & getrecommendations! Published in 2020 at "Acta Diabetologica"
DOI: 10.1007/s00592-020-01533-5
Abstract: Aims Dipeptidyl peptidase-4, a transmembrane glycoprotein expressed in various cell types, serves as a co-stimulator molecule to influence immune response. This study aimed to investigate associations between DPP-4 inhibitors and risk of autoimmune disorders in… read more here.
Keywords: dpp inhibitors; autoimmune diseases; study; type diabetes ... See more keywords
Enantioseparation of DPP-4 Inhibitors on Immobilized Crown Ether-Based Chiral Stationary Phase
Sign Up to like & getrecommendations! Published in 2018 at "Chromatographia"
DOI: 10.1007/s10337-018-3626-x
Abstract: A group of DPP-4 inhibitors such as alogliptin, linagliptin and saxagliptin were selected for enantioseparation for this study. Crown ether columns contain a chiral crown ether ring as a chiral selector is suitable for the… read more here.
Keywords: peptidase inhibitors; crown ether; dpp inhibitors; enantioseparation dpp ... See more keywords
Predicting DPP-IV inhibitors with machine learning approaches
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-017-0009-6
Abstract: Dipeptidyl peptidase IV (DPP-IV) is a promising Type 2 diabetes mellitus (T2DM) drug target. DPP-IV inhibitors prolong the action of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP), improve glucose homeostasis without weight gain, edema,… read more here.
Keywords: machine learning; dpp inhibitors; learning approaches; dpp ... See more keywords
Design, synthesis and biological evaluation of novel 1,2,3-triazole-based xanthine derivatives as DPP-4 inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Chemical Sciences"
DOI: 10.1007/s12039-020-1760-0
Abstract: Abstract Inhibitors of dipeptidyl peptidase-4 (DPP4) have been shown to be effective treatments for type 2 diabetes. A series of novel 1,2,3-triazole based xanthine derivatives were designed and evaluated for in vitro dipeptidyl peptidase-4 (DPP-4)… read more here.
Keywords: based xanthine; xanthine derivatives; dpp inhibitors; triazole based ... See more keywords
Disentangling conflicting evidence on DPP-4 inhibitors and outcomes of COVID-19: narrative review and meta-analysis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-021-01515-6
Abstract: The infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread all over the world, becoming pandemic. Several studies have shown that diabetes mellitus (DM) is an independent risk factor that increases mortality… read more here.
Keywords: review meta; analysis; dpp inhibitors; evidence ... See more keywords
The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173272
Abstract: Dipeptidyl Peptidase-4 (DPP-4) is a specific enzyme hydrolyzing the incretin hormone glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) to reduce insulin secretion, meanwhile DPP-4 inhibitors play an important role in diabetic therapy. In… read more here.
Keywords: akt gsk; dpp; dpp inhibitors; glucolipid metabolism ... See more keywords
Mechanism by which dipeptidyl peptidase-4 inhibitors increase the risk of heart failure and possible differences in heart failure risk.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of cardiology"
DOI: 10.1016/j.jjcc.2018.07.004
Abstract: Dipeptidyl peptidase-4 (DPP-4) inhibitors are oral antidiabetic drugs that safely reduce the blood glucose level over the long term. In Japan, DPP-4 inhibitors have become the oral antidiabetic drugs most frequently prescribed for patients with… read more here.
Keywords: increase risk; dpp inhibitors; heart; heart failure ... See more keywords
Design, Synthesis and Evaluation of a Series of Novel Super-long Acting DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00374
Abstract: In the present work, a novel series of trifluoromethyl substituted tetrahydropyran derivatives were rationally designed and synthesized as potent DPP-4 inhibitors with significantly improved duration time of action over current commercially available DPP-4 inhibitors. The… read more here.
Keywords: design synthesis; dpp inhibitors; evaluation series; dpp ... See more keywords
Diabetes type 2 management: what are the differences between DPP-4 inhibitors and how do you choose?
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2017.1323878
Abstract: Type 2 diabetes mellitus (T2DM) is characterized by progressive beta cell dysfunction and insulin resistance. Pharmacotherapy to treat dysregulated glucose metabolism focuses on augmenting the insulin response to hyperglycemia, improving insulin sensitivity or altering glucose… read more here.
Keywords: differences dpp; management differences; type management; dpp inhibitors ... See more keywords