Dipeptidyl Peptidase 4/Midline‐1 Axis Promotes T Lymphocyte Motility in Atherosclerosis
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204194
Abstract: T cells play a crucial role in atherosclerosis, with its infiltration preceding the formation of atheroma. However, how T‐cell infiltration is regulated in atherosclerosis remains largely unknown. Here, this work demonstrates that dipeptidyl peptidase‐4 (DPP4)… read more here.
Keywords: dipeptidyl peptidase; dpp4; motility; atherosclerosis ... See more keywords
Significance of circulatory DPP4 activity in metabolic diseases
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1709
Abstract: Dipeptidyl peptidase 4 (DPP4), also known as CD26 is a type II transmembrane protein that is released from the cell membrane in a nonclassical secretory mechanism. This exopeptidase selectively degrades varieties of substrates including incretin… read more here.
Keywords: dpp4; dpp4 activity; metabolic diseases; circulatory dpp4 ... See more keywords
Lung infection caused by Pseudomonas aeruginosa in a CD26/DPP4 deficient F344 rat model
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation Research"
DOI: 10.1007/s00011-019-01236-w
Abstract: BackgroundPseudomonas aeruginosa (PA) is the most important opportunistic pathogen in causing nosocomial infections and, furthermore, poses a permanent threat for severe chronic infections in patients with cystic fibrosis or COPD. The transmembrane protein CD26 with… read more here.
Keywords: dpp4; lung infection; cd26; cd26 dpp4 ... See more keywords
DPP4 gene silencing inhibits proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through suppression of the MAPK pathway
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-020-01455-7
Abstract: Purpose Papillary thyroid carcinoma (PTC) is characterized by epithelial malignancy and is the most prevalent thyroid neoplasm with the best overall prognosis. Notably, recently published studies have indicated remarkably high expression of dipeptidyl peptidase 4 (DPP4)… read more here.
Keywords: dpp4; mapk pathway; expression; ptc ... See more keywords
Insight into the Role of Active Site Protonation States and Water Molecules in the Catalytic Inhibition of DPP4 by Vildagliptin
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01558
Abstract: Vildagliptin (VIL) is an antidiabetic drug that inhibits dipeptidyl peptidase-4 (DPP4) through a covalent mechanism. The molecular bases for this inhibitory process have been addressed experimentally and computationally. Nevertheless, relevant issues remain unknown such as… read more here.
Keywords: dpp4; water; protonation states; protonation ... See more keywords
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-021-00818-x
Abstract: Dipeptidyl peptidase-4 (DPP4) plays a crucial role in regulating the bioactivity of glucagon-like peptide-1 (GLP-1) that enhances insulin secretion and pancreatic β-cell proliferation, making it a therapeutic target for type 2 diabetes. Although the crystal… read more here.
Keywords: v486m; dpp4; activity dpp4; mutation ... See more keywords
IBD — a potential adverse effect of DDP4 inhibitors in T2DM
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-018-0007-3
Abstract: Dipeptidyl peptidase 4 (DPP4) inhibitors are increasingly being used to treat patients with type 2 diabetes mellitus (T2DM); however, new research suggests that this class of drugs could increase the risk of incident inflammatory bowel… read more here.
Keywords: dpp4; effect ddp4; ibd potential; dpp4 inhibitors ... See more keywords
Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth
Sign Up to like & getrecommendations! Published in 2019 at "Nature Immunology"
DOI: 10.1038/s41590-019-0321-5
Abstract: Post-translational modification of chemokines mediated by the dipeptidyl peptidase DPP4 (CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition enhances T cell migration and tumor immunity by preserving functional chemokine CXCL10. By… read more here.
Keywords: dpp4; eosinophil mediated; peptidase dpp4; dipeptidyl peptidase ... See more keywords
Do novel drugs for diabetes help in COVID‐19? Another brick in the wall?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.13050
Abstract: To the Editor: Recently we have read an interesting report concerning a mild course of novel coronavirus disease 2019 (COVID-19) in children. The disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is defined… read more here.
Keywords: dpp4; brick wall; covid; sars cov ... See more keywords
Targeting CD26/DPP4 in organ fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of pharmacology"
DOI: 10.1111/bph.15967
Abstract: CD26/DPP4 is an exopeptidase that is expressed as a transmembrane protein in many organs but also present in a circulating soluble form. Beyond its enzymatic and co-stimulatory activity, CD26/DPP4 is involved in the pathogenesis of… read more here.
Keywords: organ fibrosis; targeting cd26; dpp4; cd26 dpp4 ... See more keywords
Signaling crosstalk between Dipeptidyl Peptidase 4 and Angiotensin II-AT1R plays a role in proximal tubule NHE3 regulation and salt sensitive hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732918
Abstract: Background: Salt sensitivity to hypertension occurs in 50-60% of all hypertensive patients and is more common in overweight/obese, females and aging population. In salt sensitive hypertension, the renin-angiotensin system (RAS) is known to play a… read more here.
Keywords: hypertension; dpp4; physiology; proximal tubule ... See more keywords