Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer’s disease in the European American population
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica"
DOI: 10.1007/s00401-021-02271-w
Abstract: Using linkage analysis in a large Dutch early onset AD (EOAD) family, Rademakers et al. identified a candidate region chromosome 7q36 [7]. Follow-up studies of this region revealed a chromosomal inversion disrupting the coding sequence… read more here.
Keywords: supplementary table; alzheimer disease; european american; cohort ... See more keywords
Reply: Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer’s disease in the European American population
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neuropathologica"
DOI: 10.1007/s00401-021-02277-4
Abstract: We appreciate the work performed by Kirola et al. [3] in attempting to replicate our genetic findings in DPP6 [1]. Kirola et al. investigated association of DPP6 with Alzheimer’s disease (AD) in whole exome sequencing… read more here.
Keywords: role dpp6; alzheimer disease; disease; kirola ... See more keywords
A novel DPP6 variant in Chinese families causes early repolarization syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111561
Abstract: Previous studies demonstrated that variants in dipeptidyl aminopeptidase-like protein-6 (DPP6) are involved in idiopathic ventricular fibrillation. However, its role in early repolarization syndrome (ERS) remains largely elusive. The aim of this study is to determine… read more here.
Keywords: chinese families; variant; dpp6; early repolarization ... See more keywords
P933Novel missense variant in DPP6 in familial ventricular fibrillation
Sign Up to like & getrecommendations! Published in 2020 at "Europace"
DOI: 10.1093/europace/euaa162.186
Abstract: This work was supported by an ESC Research Grant to A.R., and by The Netherlands CardioVascular Research Initiative (CVON PREDICT2), Den Haag, The N The DPP6 gene, encoding dipeptidyl aminopeptidase-like protein-6, has been associated with… read more here.
Keywords: variant; missense variant; familial ventricular; ventricular fibrillation ... See more keywords
The Mediation Effects of Aluminum in Plasma and Dipeptidyl Peptidase Like Protein 6 (DPP6) Polymorphism on Renal Function via Genome-Wide Typing Association
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph181910484
Abstract: Aluminum (Al) toxicity is related to renal failure and the failure of other systems. Although there were some genome-wide association studies (GWAS) in Australia and England, there were no GWAS about Han Chinese to our… read more here.
Keywords: genome wide; mediation; association; renal function ... See more keywords
Modulation of KV4.3-KChIP2 Channels by IQM-266: Role of DPP6 and KCNE2
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169170
Abstract: The transient outward potassium current (Itof) is generated by the activation of KV4 channels assembled with KChIP2 and other accessory subunits (DPP6 and KCNE2). To test the hypothesis that these subunits modify the channel pharmacology,… read more here.
Keywords: iqm 266; kcne2; dpp6; kchip2 ... See more keywords
Neuronal Roles of the Multifunctional Protein Dipeptidyl Peptidase-like 6 (DPP6)
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DOI: 10.3390/ijms23169184
Abstract: The concerted action of voltage-gated ion channels in the brain is fundamental in controlling neuronal physiology and circuit function. Ion channels often associate in multi-protein complexes together with auxiliary subunits, which can strongly influence channel… read more here.
Keywords: roles multifunctional; neuronal roles; function; dpp6 ... See more keywords