Dppa3 in pluripotency maintenance of ES cells and early embryogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28063
Abstract: Embryonic development is precisely regulated by a network of signal pathways and specific genes. Dppa3 (also known as Pgc7 or Stella) plays an important role in early embryonic development during the cleavage stage as a… read more here.
Keywords: dppa3; pluripotency maintenance; early embryogenesis;
Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3
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DOI: 10.1038/s42003-024-06434-9
Abstract: DNA methylation maintenance is essential for cell fate inheritance. In differentiated cells, this involves orchestrated actions of DNMT1 and UHRF1. In mice, the high-affinity binding of DPPA3 to the UHRF1 PHD finger regulates UHRF1 chromatin… read more here.
Keywords: phd finger; uhrf1 phd; human dppa3; dppa3 ... See more keywords
Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1082
Abstract: Ubiquitin-like with PHD and RING finger domain-containing protein 1 (UHRF1)-dependent DNA methylation is essential for maintaining cell fate during cell proliferation. Developmental pluripotency-associated 3 (DPPA3) is an intrinsically disordered protein that specifically interacts with UHRF1… read more here.
Keywords: uhrf1 phd; finger; dppa3; structural basis ... See more keywords