Assay development and inhibition of the Mt-DprE2 essential reductase from Mycobacterium tuberculosis
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DOI: 10.1099/mic.0.001288
Abstract: DprE2 is an essential enzyme in the synthesis of decaprenylphosphoryl-β-d-arabinofuranose (DPA) and subsequently arabinogalactan, and is a significant new drug target for M. tuberculosis . Two compounds from the GSK-177 box set, GSK301A and GSK032A,… read more here.
Keywords: inhibition; assay development; tuberculosis; dpre2 ... See more keywords