Role of chromatin modulator Dpy30 in osteoclast differentiation and function.
Sign Up to like & getrecommendations! Published in 2022 at "Bone"
DOI: 10.1016/j.bone.2022.116379
Abstract: Osteoclasts are the principal bone resorption cells crucial for homeostatic bone remodeling and pathological bone destruction. Increasing data demonstrate a vital role of histone methylation in osteoclastogenesis. As an integral core subunit of H3K4 methyltransferases,… read more here.
Keywords: bone; differentiation; differentiation function; dpy30 ... See more keywords
Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23268-9
Abstract: Recent cryo-EM structures show the highly dynamic nature of the MLL1-NCP (nucleosome core particle) interaction. Functional implication and regulation of such dynamics remain unclear. Here we show that DPY30 and the intrinsically disordered regions (IDRs)… read more here.
Keywords: disordered regions; dpy30; mll set1; dpy30 ash2l ... See more keywords
The DPY30-H3K4me3 Axis-Mediated PD-L1 Expression in Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s377678
Abstract: Background DPY30 is a common subunit of the human SET1/MLL complex and is an essential protein required for the activity of SET1/MLL methyltransferase. DPY30 regulates the histone H3K4 modification, and dysfunction of DPY30 might contribute… read more here.
Keywords: dpy30; h3k4me3 axis; melanoma; expression ... See more keywords
DPY30 is required for the enhanced proliferation, motility and epithelial-mesenchymal transition of epithelial ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2018.3869
Abstract: Epithelial ovarian cancer (EOC) is one of the most lethal gynecological malignancies and is known to be associated with the accumulation of various genetic and epigenetic alterations. As a member of the human histone-lysine N-methyltransferase… read more here.
Keywords: epithelial ovarian; dpy30; proliferation; expression ... See more keywords
Identification and validation of DPY30 as a prognostic biomarker and tumor immune microenvironment infiltration characterization in esophageal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Letters"
DOI: 10.3892/ol.2022.13654
Abstract: Esophageal cancer (ESCA) is a lethal malignancy and is associated with the alterations of various genes and epigenetic modifications. The protein dpy-30 homolog (DPY30) is a core member of histone H3K4 methylation catalase and its… read more here.
Keywords: dpy30; expression; tumor immune; analysis ... See more keywords