Upfront DPYD Genotyping and Toxicity Associated with Fluoropyrimidine-Based Concurrent Chemoradiotherapy for Oropharyngeal Carcinomas: A Work in Progress
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DOI: 10.3390/curroncol29020045
Abstract: Simple Summary The combination of carboplatin and 5-fluorouracil (5-FU) is effective when used concurrently with radiotherapy for locoregionally advanced oropharyngeal carcinomas. DPYD polymorphisms can be associated with an increased risk of severe toxicity to fluoropyrimidines.… read more here.
Keywords: dpyd genotyping; dpyd; toxicity; upfront dpyd ... See more keywords
DPYD Genotyping, Fluoropyrimidine Dosage and Toxicity: An Umbrella Review of Systematic Reviews
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DOI: 10.3390/ph18050727
Abstract: Background/Objectives: Fluoropyrimidines are widely used chemotherapeutic agents in various solid tumors. Germline variants in the DPYD gene, which encodes the enzyme dihydropyrimidine dehydrogenase (DPD), are known to impair drug metabolism and increase the risk of… read more here.
Keywords: toxicity umbrella; dpyd genotyping; systematic reviews; toxicity ... See more keywords