Characterization of T‐cell receptor transgenic mice recognizing immunodominant HLA‐DQ2.5‐restricted gluten epitopes
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048859
Abstract: We created a TCR transgenic mouse with CD4+ T cells recognizing the immunodominant DQ2.5-glia-ω2 gluten epitope. We show that these cells respond to deamidated gluten feed in vivo and compare them to previously published α2-… read more here.
Keywords: dq2; recognizing immunodominant; receptor transgenic; characterization cell ... See more keywords
Is the double gene dose of DQ2.5 or DQ2.5/DQ2.2 an involved factor in the clinical features of celiac disease?
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2019.1647283
Abstract: Abstract Objectives: Celiac disease (CD) is barely known if the quantitative effect of DQB1*02 (DQ2) double dose in antigen presentation to T-cells has translation into the clinic. For this, we have conducted a case-control study… read more here.
Keywords: control group; dq2; dq2 dq2; celiac disease ... See more keywords
When type 1 diabetes meets celiac disease
Sign Up to like & getrecommendations! Published in 2018 at "HLA"
DOI: 10.1111/tan.13441
Abstract: Type1 diabetes (T1D) and celiac disease (CD) may occur together. HLA‐DQ8 and DQ2 are key genetic risk factors in both. Overall, the patients with co‐existing T1D and CD (T1D+CD) were shown to have HLA profile… read more here.
Keywords: t1d; risk; dq2; celiac disease ... See more keywords
The distribution of HLA DQ2 and DQ8 haplotypes and their association with health indicators in a general Danish population
Sign Up to like & getrecommendations! Published in 2018 at "United European Gastroenterology Journal"
DOI: 10.1177/2050640618765506
Abstract: Background Human leukocyte antigen (HLA) DQ2 and DQ8 are important risk factors for some autoimmune diseases such as celiac disease (CD), but their possible role in other diseases and health conditions is not fully explored.… read more here.
Keywords: dq2; dq2 dq8; dq8; population ... See more keywords
Meta-Analysis and Systematic Review of HLA DQ2/DQ8 in Adults with Celiac Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021188
Abstract: Although people with human leukocyte antigens (HLA) DQ2 and/or DQ8 are more likely to develop celiac disease (CD), the condition cannot be fully explained by this genetic predisposition alone. Multiple, as yet unidentified, factors contribute… read more here.
Keywords: hla dq2; celiac disease; dq2; dq2 dq8 ... See more keywords