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Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109953
Abstract: Receptor clustering is the first and critical step to activate apoptosis by death receptor-5 (DR5). The recent discovery of the autoinhibitory DR5 ectodomain has challenged the long-standing view of its mechanistic activation by the natural…
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Keywords:
residues regulates;
dr5 antibodies;
positively charged;
charged residues ... See more keywords
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Published in 2018 at "Cell Death Discovery"
DOI: 10.1038/s41420-018-0035-8
Abstract: BIX-01294 (BIX), a G9a histone methyltransferase inhibitor, has been reported for its anti-proliferative and anticancer activities against various cancer cell lines. In this study, we investigated whether BIX could sensitize TRAIL-mediated apoptosis in various cancer…
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Keywords:
apoptosis;
induced apoptosis;
expression;
dr5 ... See more keywords
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1
Published in 2019 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297919060051
Abstract: The cytokine TRAIL induces apoptosis in tumor cells of various origin without affecting normal cells. Clinical trials of TRAIL-receptor (DR4 and DR5) agonists (recombinant TRAIL or death receptors antibodies) have largely failed because most human…
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Keywords:
efficient method;
cytokine trail;
dr5;
trail ... See more keywords
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1
Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-518
Abstract: Death receptor 5 (DR5) is a member of the tumor necrosis factor (TNF) receptor superfamily that binds TNF-related apoptosis inducing ligand (TRAIL) to induce receptor trimerization and activate extrinsic apoptotic pathways. DR5 is expressed on…
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Keywords:
igm 8444;
dr5;
receptor;
cell ... See more keywords
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Published in 2023 at "Natural Product Communications"
DOI: 10.1177/1934578x221144580
Abstract: Death receptor 5 (DR5) is an apoptosis-inducing membrane receptor that mediates cell death in several life-threatening conditions. There is a crucial need for the discovery of DR5 antagonists for the therapeutic intervention of conditions in…
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Keywords:
death receptor;
death;
dr5;
trail induced ... See more keywords
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Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26407
Abstract: Activation of death receptor 5 (DR5) to induce apoptosis in cancer cells is an attractive strategy for cancer therapy. However, many tumor cell lines and primary tumors are resistant to DR5 targeted agents including recombinant…
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Keywords:
dr5;
death receptor;
tubulin;
apoptosis ... See more keywords
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1
Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23115860
Abstract: In the last two decades, bifunctional proteins have been created by genetic and protein engineering methods to increase therapeutic effects in various diseases, including cancer. Unlike conventional small molecule or monotargeted drugs, bifunctional proteins have…
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Keywords:
trail;
srh dr5;
fusion protein;
dr5 ... See more keywords
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1
Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23168987
Abstract: The uncontrolled proliferation of malignant cells in growing tumors results in the generation of different stressors in the tumor microenvironment, such as nutrient shortage, hypoxia and acidosis, among others, that disrupt endoplasmic reticulum (ER) homeostasis…
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Keywords:
endoplasmic reticulum;
stress;
apoptosis;
dr5 ... See more keywords
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Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15081029
Abstract: Death receptor 5 (DR5) is a membrane protein that mediates exogenous apoptosis. Based on its function, it is considered to be a target for the treatment of cancers including prostate cancer. It is encouraging to…
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Keywords:
function;
prostate cancer;
molecules prostate;
small molecules ... See more keywords
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Published in 2021 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics13091413
Abstract: Nanoparticles based on the biocompatible amphiphilic poly(N-vinylpyrrolidone) (Amph-PVP) derivatives are promising for drug delivery. Amph-PVPs self-aggregate in aqueous solutions with the formation of micellar nanoscaled structures. Amph-PVP nanoparticles are able to immobilize therapeutic molecules under…
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Keywords:
delivery;
amph pvp;
dr5;
antitumor ... See more keywords