Albumin-Hitchhiking Drug Delivery to Tumor-draining Lymph Nodes Precisely Boosts Tumor-Specific Immunity through Autophagy Modulation of Immune Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211055
Abstract: Tumor-draining lymph nodes (TDLNs) are the first sites where tumor components reach and dendritic cells (DCs) present tumor-associated antigens to T cells. DCs rely on autophagy to process tumor antigens into epitope peptides to form… read more here.
Keywords: draining lymph; immunity; tumor draining; lymph nodes ... See more keywords
Melanoma‐derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12197
Abstract: Abstract Tumour‐draining lymph nodes (LNs) undergo massive remodelling including expansion of the lymphatic sinuses, a process that has been linked to lymphatic metastasis by creation of a pre‐metastatic niche. However, the signals leading to these… read more here.
Keywords: derived extracellular; extracellular vesicles; vesicles mediate; draining lymph ... See more keywords
Reverse immune suppressive microenvironment in tumor draining lymph nodes to enhance anti-PD1 immunotherapy via nanovaccine complexed microneedle
Sign Up to like & getrecommendations! Published in 2020 at "Nano Research"
DOI: 10.1007/s12274-020-2737-5
Abstract: The maturation of dendritic cells (DCs) and infiltration effector T cells in tumor-draining lymph node (tdLN) and tumor tissue are crucial for immunotherapy. Despite constructive progresses have been made with anti-programmed death-1 (anti-PD1) checkpoint blockade… read more here.
Keywords: draining lymph; anti pd1; immunotherapy; nanovaccine complexed ... See more keywords
TCR sequencing analysis of cancer tissues and tumor draining lymph nodes in colorectal cancer patients
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DOI: 10.1080/2162402x.2019.1588085
Abstract: ABSTRACT Tumor draining lymph nodes (TDLNs) are located in the routes of lymphatic drainage from a primary tumor and have the highest risk of metastasis in various types of solid tumors. TDLNs are also considered… read more here.
Keywords: metastasis; draining lymph; cancer; tumor draining ... See more keywords
Indirect activation of rhesus macaque (Macaca mulatta) NK cells in oral and mucosal draining lymph nodes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Primatology"
DOI: 10.1111/jmp.12371
Abstract: The oral mucosae and draining lymph nodes are primary entry points for invading pathogens, particularly during immunosuppressive HIV/SIV infections. Innate immunity against oral stimuli, including natural killer (NK) cells, is understudied. Herein, we demonstrate functional… read more here.
Keywords: draining lymph; rhesus macaque; lymph nodes; macaque macaca ... See more keywords
Photodynamic Therapy‐Induced Cyclooxygenase 2 Expression in Tumor‐Draining Lymph Nodes Regulates B‐Cell Expression of Interleukin 17 and Neutrophil Infiltration
Sign Up to like & getrecommendations! Published in 2022 at "Photochemistry and Photobiology"
DOI: 10.1111/php.13601
Abstract: Photodynamic therapy (PDT) is an effective anticancer modality approved by the U.S. Food and Drug Administration (FDA). Antitumor immunity can be augmented during PDT by inducing sterile inflammation in an acute manner, and this process… read more here.
Keywords: draining lymph; neutrophil infiltration; expression; tumor draining ... See more keywords
Abstract 4465: Evaluation of tumor draining lymph nodes in dogs with spontaneously arising osteosarcoma using single-cell sequencing
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4465
Abstract: Tumor draining lymph nodes (TDLNs) function as an anatomic niche which primes immune cells to generate anti-cancer responses. While tumors are frequently staged based on the presence or absence of TDLN metastasis, mechanisms for how… read more here.
Keywords: cell; draining lymph; tumor draining; dogs spontaneously ... See more keywords
Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-21-0778
Abstract: Communication between tumors and the stroma of tumor-draining lymph nodes (TDLN) exists before metastasis arises, altering the structure and function of the TDLN niche. Transcriptional profiling of fibroblastic reticular cells (FRC), the dominant stromal population… read more here.
Keywords: lymph node; draining lymph; tumor derived; lactic acid ... See more keywords
Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00206
Abstract: For full activation of naïve adaptive lymphocytes in skin-draining lymph nodes (LNs), presentation of peptide:MHC complexes by LN-resident and skin-derived dendritic cells (DCs) that encountered antigens (Ags) is an absolute prerequisite. To get to the… read more here.
Keywords: draining lymph; lymph nodes; migration; adaptive immunity ... See more keywords
Influence of the Draining Lymph Nodes and Organized Lymphoid Tissue Microarchitecture on Susceptibility to Intradermal Trypanosoma brucei Infection
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01118
Abstract: Infection of the mammalian host with African trypanosomes begins when the tsetse fly vector injects the parasites into the skin dermis during blood feeding. After injection into the skin, trypanosomes first accumulate in the draining… read more here.
Keywords: draining lymph; lymph nodes; brucei infection; infection ... See more keywords
Exposure to solar ultraviolet radiation establishes a novel immune suppressive lipidome in skin-draining lymph nodes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1045731
Abstract: The ability of ultraviolet radiation to suppress the immune system is thought to be central to both its beneficial (protection from autoimmunity) and detrimental (carcinogenic) effects. Previous work revealed a key role for lipids particularly… read more here.
Keywords: draining lymph; ultraviolet radiation; skin draining; immune suppressive ... See more keywords