Albumin-Hitchhiking Drug Delivery to Tumor-draining Lymph Nodes Precisely Boosts Tumor-Specific Immunity through Autophagy Modulation of Immune Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211055
Abstract: Tumor-draining lymph nodes (TDLNs) are the first sites where tumor components reach and dendritic cells (DCs) present tumor-associated antigens to T cells. DCs rely on autophagy to process tumor antigens into epitope peptides to form… read more here.
Keywords: draining lymph; immunity; tumor draining; lymph nodes ... See more keywords
Melanoma‐derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12197
Abstract: Abstract Tumour‐draining lymph nodes (LNs) undergo massive remodelling including expansion of the lymphatic sinuses, a process that has been linked to lymphatic metastasis by creation of a pre‐metastatic niche. However, the signals leading to these… read more here.
Keywords: derived extracellular; extracellular vesicles; vesicles mediate; draining lymph ... See more keywords
Reverse immune suppressive microenvironment in tumor draining lymph nodes to enhance anti-PD1 immunotherapy via nanovaccine complexed microneedle
Sign Up to like & getrecommendations! Published in 2020 at "Nano Research"
DOI: 10.1007/s12274-020-2737-5
Abstract: The maturation of dendritic cells (DCs) and infiltration effector T cells in tumor-draining lymph node (tdLN) and tumor tissue are crucial for immunotherapy. Despite constructive progresses have been made with anti-programmed death-1 (anti-PD1) checkpoint blockade… read more here.
Keywords: draining lymph; anti pd1; immunotherapy; nanovaccine complexed ... See more keywords
TCR sequencing analysis of cancer tissues and tumor draining lymph nodes in colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2019 at "OncoImmunology"
DOI: 10.1080/2162402x.2019.1588085
Abstract: ABSTRACT Tumor draining lymph nodes (TDLNs) are located in the routes of lymphatic drainage from a primary tumor and have the highest risk of metastasis in various types of solid tumors. TDLNs are also considered… read more here.
Keywords: metastasis; draining lymph; cancer; tumor draining ... See more keywords
Indirect activation of rhesus macaque (Macaca mulatta) NK cells in oral and mucosal draining lymph nodes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Primatology"
DOI: 10.1111/jmp.12371
Abstract: The oral mucosae and draining lymph nodes are primary entry points for invading pathogens, particularly during immunosuppressive HIV/SIV infections. Innate immunity against oral stimuli, including natural killer (NK) cells, is understudied. Herein, we demonstrate functional… read more here.
Keywords: draining lymph; rhesus macaque; lymph nodes; macaque macaca ... See more keywords
Photodynamic Therapy‐Induced Cyclooxygenase 2 Expression in Tumor‐Draining Lymph Nodes Regulates B‐Cell Expression of Interleukin 17 and Neutrophil Infiltration
Sign Up to like & getrecommendations! Published in 2022 at "Photochemistry and Photobiology"
DOI: 10.1111/php.13601
Abstract: Photodynamic therapy (PDT) is an effective anticancer modality approved by the U.S. Food and Drug Administration (FDA). Antitumor immunity can be augmented during PDT by inducing sterile inflammation in an acute manner, and this process… read more here.
Keywords: draining lymph; neutrophil infiltration; expression; tumor draining ... See more keywords
Abstract 4465: Evaluation of tumor draining lymph nodes in dogs with spontaneously arising osteosarcoma using single-cell sequencing
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4465
Abstract: Tumor draining lymph nodes (TDLNs) function as an anatomic niche which primes immune cells to generate anti-cancer responses. While tumors are frequently staged based on the presence or absence of TDLN metastasis, mechanisms for how… read more here.
Keywords: cell; draining lymph; tumor draining; dogs spontaneously ... See more keywords
Abstract 5816: TCR clonal tracking maps tumor-draining lymph nodes as reservoirs fueling neoadjuvant PD-1 blockade in resectable NSCLC
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-5816
Abstract: PD-1 blockade with platinum chemotherapy (chemo/IO) has transformed treatment for resectable non-small cell lung cancer (NSCLC). However, gaps in understanding the adaptive T cell response impede progress, resulting in a lack of predictive biomarkers and… read more here.
Keywords: tumor draining; cell; tumor; draining lymph ... See more keywords
Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-21-0778
Abstract: Communication between tumors and the stroma of tumor-draining lymph nodes (TDLN) exists before metastasis arises, altering the structure and function of the TDLN niche. Transcriptional profiling of fibroblastic reticular cells (FRC), the dominant stromal population… read more here.
Keywords: lymph node; draining lymph; tumor derived; lactic acid ... See more keywords
Nanoliposomal PD-1 antagonist target tumor-draining lymph nodes to revitalize T cells and improve anti-tumor effect in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-025-03537-1
Abstract: Tumor-draining lymph nodes (TdLNs) are pivotal in tumor immunotherapy, including the action of immune checkpoint inhibitors such as PD-1/PD-L1 blockade. However, fully harnessing the therapeutic potential of TdLNs to improve clinical outcomes remains a significant… read more here.
Keywords: tumor draining; tdlns; lymph nodes; tumor ... See more keywords
Unleashing the therapeutic potential of tumor-draining lymph nodes: spotlight on bladder cancer
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-024-05864-7
Abstract: Tumor-draining lymph nodes (TDLNs) are often involved during the metastasis of bladder cancer (BC), which is associated with a poor prognosis. Recent studies have shown that TDLNs are a major source of host anti-tumor immunity,… read more here.
Keywords: tumor draining; lymph nodes; tumor; bladder cancer ... See more keywords