The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0490-y
Abstract: Overexpression of the oncogene MYBL2 (B-Myb) is associated with increased cell proliferation and serves as a marker of poor prognosis in cancer. However, the mechanism by which B-Myb alters the cell cycle is not fully… read more here.
Keywords: cell cycle; dream complex; myb;
The tetraspanin CD53 protects stressed hematopoietic stem cells via promotion of DREAM complex–mediated quiescence
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DOI: 10.1182/blood.2022016929
Abstract: Key Points • CD53 is upregulated in HSCs in response to various inflammatory and proliferative stressors.• CD53 promotes HSC return to quiescence via promotion of the DREAM complex activity and downregulation of cycling-associated genes. read more here.
Keywords: cd53; quiescence; dream complex; via promotion ... See more keywords
Restoring the DREAM Complex Inhibits the Proliferation of High-Risk HPV Positive Human Cells
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DOI: 10.3390/cancers13030489
Abstract: Simple Summary Human papillomaviruses are responsible for around 5% of all cancers, and to date there are no anti-viral therapeutics available for treating these cancers. In this report we demonstrate that in HPV positive cells… read more here.
Keywords: dream; dream complex; hpv positive; proliferation ... See more keywords
The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14143491
Abstract: Simple Summary Cancer develops due to the expression of genes that promote cell growth and the repression of genes that limit growth. Epigenetics is a mechanism that regulates gene expression via the chemical modification of… read more here.
Keywords: dream complex; cell growth; cancer; cbx2 ... See more keywords