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   Articles with "drg" as a keyword



Silicon Nanowire Mats Enable Advanced Bioelectrical Recordings in Primary DRG Cell Cultures

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recommendations! Published in 2025 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202500379

Abstract: Primary dorsal root ganglion (DRG) cell cultures provide a valuable model for studying in vitro sensory transduction, neuropathies, and chronic pain, as they replicate the in vivo heterogeneity of DRG neurons and non‐neuronal cells. However,… read more here.

Keywords: silicon nanowire; cell; nanowire mats; cell cultures ... See more keywords

Piezo1 Regulates Stiffness‐Dependent DRG Axon Regeneration via Modifying Cytoskeletal Dynamics

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202405705

Abstract: Despite medical interventions, the regenerative capacity of the peripheral nervous system is limited. Dorsal root ganglion (DRG) neurons possess the capacity to detect mechanical signals from their microenvironment, but the impact and mechanism by which… read more here.

Keywords: drg neurons; axon regrowth; axon regeneration; regeneration ... See more keywords

DNMT3a‐triggered downregulation of K2p1.1 gene in primary sensory neurons contributes to paclitaxel‐induced neuropathic pain

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recommendations! Published in 2019 at "International Journal of Cancer"

DOI: 10.1002/ijc.32155

Abstract: Antineoplastic drugs induce dramatic transcriptional changes in dorsal root ganglion (DRG) neurons, which may contribute to chemotherapy‐induced neuropathic pain. K2p1.1 controls neuronal excitability by setting the resting membrane potential. Here, we report that systemic injection… read more here.

Keywords: k2p1; paclitaxel induced; dnmt3a; drg ... See more keywords

Toll-Like Receptor 4 (TLR4) Promotes DRG Regeneration and Repair after Sciatic Nerve Injury via the ERK-NF-kB Pathway

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recommendations! Published in 2024 at "Molecular Neurobiology"

DOI: 10.1007/s12035-024-04483-z

Abstract: Previously, we found that the expression of Toll-like receptor 4 (TLR4) is altered after sciatic nerve injury, and its differential expression plays a key role in recovery. However, the mechanisms by which TLR4 affects neuronal… read more here.

Keywords: sciatic nerve; tlr4; injury; regeneration ... See more keywords

CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons

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recommendations! Published in 2020 at "Neurotherapeutics"

DOI: 10.1007/s13311-020-00931-5

Abstract: Chemotherapy-induced peripheral neuropathic pain (CIPNP) often occurs in cancer patients treated with antineoplastic drugs. Therapeutic management of CIPNP is very limited, at least in part due to the largely unknown mechanisms that underlie CIPNP genesis.… read more here.

Keywords: dnmt3a; paclitaxel induced; drg; neurons creb ... See more keywords
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Do hospitals respond to changing incentive structures? Evidence from Medicare's 2007 DRG restructuring.

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recommendations! Published in 2020 at "Journal of health economics"

DOI: 10.1016/j.jhealeco.2020.102319

Abstract: In 2007, the Centers for Medicare and Medicaid restructured the diagnosis related group (DRG) system by expanding the number of categories within a DRG to account for complications present within certain conditions. This change allows… read more here.

Keywords: changing incentive; drg; hospitals respond; respond changing ... See more keywords

The role of Celsr3 in the development of central somatosensory projections from dorsal root ganglia

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recommendations! Published in 2017 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2017.07.040

Abstract: Dorsal root ganglion (DRG) neurons receive peripheral somatosensory information and send orderly projections to second-order relay nuclei in the spinal cord and in the brainstem. Atypical cadherin Celsr3 is known to play a critical role… read more here.

Keywords: drg; somatosensory; dorsal root; role ... See more keywords

Fluoroscopy-guided approach to the lumbar dorsal root ganglion in dogs: cadaver study in Beagles.

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recommendations! Published in 2020 at "Veterinary anaesthesia and analgesia"

DOI: 10.1016/j.vaa.2020.03.004

Abstract: OBJECTIVE To evaluate an approach to the canine lumbar dorsal root ganglion (DRG), a significant contributor to the pain pathway, using new methylene blue staining. STUDY DESIGN Prospective randomized study. ANIMALS A total of three… read more here.

Keywords: drg; lumbar dorsal; study; approach ... See more keywords

CaMK II γ down regulation protects dorsal root ganglion neurons from ropivacaine hydrochloride neurotoxicity

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-05678-2

Abstract: T-type calcium channels are intimately involved in the local anesthetics neurotoxicity. Does CaMKIIγ regulate T-type calcium currents in local anesthetics neurotoxicity? This study generated pAd-CaMKIIγ and pAd-shRNA adenovirus vectors to up- and down-regulate CaMKIIγ mRNA… read more here.

Keywords: ropivacaine hydrochloride; drg; root ganglion; dorsal root ... See more keywords

The influence of adverse events on inpatient outcomes in a tertiary hospital using a diagnosis-related group database

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-69283-w

Abstract: Adverse events (AEs) are a significant concern for healthcare systems. However, it is difficult to evaluate their influence because of the complexity of various medical services. This study aimed to assess the influence of AEs… read more here.

Keywords: diagnosis; database; adverse events; influence ... See more keywords

Selectivity of afferent microstimulation at the DRG using epineural and penetrating electrode arrays.

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recommendations! Published in 2019 at "Journal of neural engineering"

DOI: 10.1088/1741-2552/ab4a24

Abstract: We have shown previously that microstimulation of the lumbar dorsal root ganglia (L5-L7 DRG) using penetrating microelectrodes selectively recruits distal branches of the sciatic and femoral nerves in an acute preparation. However, a variety of… read more here.

Keywords: drg; stimulation; microstimulation; penetrating electrodes ... See more keywords