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   Articles with "drg" as a keyword



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DNMT3a‐triggered downregulation of K2p1.1 gene in primary sensory neurons contributes to paclitaxel‐induced neuropathic pain

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recommendations! Published in 2019 at "International Journal of Cancer"

DOI: 10.1002/ijc.32155

Abstract: Antineoplastic drugs induce dramatic transcriptional changes in dorsal root ganglion (DRG) neurons, which may contribute to chemotherapy‐induced neuropathic pain. K2p1.1 controls neuronal excitability by setting the resting membrane potential. Here, we report that systemic injection… read more here.

Keywords: k2p1; paclitaxel induced; dnmt3a; drg ... See more keywords
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CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons

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recommendations! Published in 2020 at "Neurotherapeutics"

DOI: 10.1007/s13311-020-00931-5

Abstract: Chemotherapy-induced peripheral neuropathic pain (CIPNP) often occurs in cancer patients treated with antineoplastic drugs. Therapeutic management of CIPNP is very limited, at least in part due to the largely unknown mechanisms that underlie CIPNP genesis.… read more here.

Keywords: dnmt3a; paclitaxel induced; drg; neurons creb ... See more keywords
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Do hospitals respond to changing incentive structures? Evidence from Medicare's 2007 DRG restructuring.

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recommendations! Published in 2020 at "Journal of health economics"

DOI: 10.1016/j.jhealeco.2020.102319

Abstract: In 2007, the Centers for Medicare and Medicaid restructured the diagnosis related group (DRG) system by expanding the number of categories within a DRG to account for complications present within certain conditions. This change allows… read more here.

Keywords: changing incentive; drg; hospitals respond; respond changing ... See more keywords
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The role of Celsr3 in the development of central somatosensory projections from dorsal root ganglia

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recommendations! Published in 2017 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2017.07.040

Abstract: Dorsal root ganglion (DRG) neurons receive peripheral somatosensory information and send orderly projections to second-order relay nuclei in the spinal cord and in the brainstem. Atypical cadherin Celsr3 is known to play a critical role… read more here.

Keywords: drg; somatosensory; dorsal root; role ... See more keywords
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Fluoroscopy-guided approach to the lumbar dorsal root ganglion in dogs: cadaver study in Beagles.

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recommendations! Published in 2020 at "Veterinary anaesthesia and analgesia"

DOI: 10.1016/j.vaa.2020.03.004

Abstract: OBJECTIVE To evaluate an approach to the canine lumbar dorsal root ganglion (DRG), a significant contributor to the pain pathway, using new methylene blue staining. STUDY DESIGN Prospective randomized study. ANIMALS A total of three… read more here.

Keywords: drg; lumbar dorsal; study; approach ... See more keywords
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CaMK II γ down regulation protects dorsal root ganglion neurons from ropivacaine hydrochloride neurotoxicity

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-05678-2

Abstract: T-type calcium channels are intimately involved in the local anesthetics neurotoxicity. Does CaMKIIγ regulate T-type calcium currents in local anesthetics neurotoxicity? This study generated pAd-CaMKIIγ and pAd-shRNA adenovirus vectors to up- and down-regulate CaMKIIγ mRNA… read more here.

Keywords: ropivacaine hydrochloride; drg; root ganglion; dorsal root ... See more keywords
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Selectivity of afferent microstimulation at the DRG using epineural and penetrating electrode arrays.

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recommendations! Published in 2019 at "Journal of neural engineering"

DOI: 10.1088/1741-2552/ab4a24

Abstract: We have shown previously that microstimulation of the lumbar dorsal root ganglia (L5-L7 DRG) using penetrating microelectrodes selectively recruits distal branches of the sciatic and femoral nerves in an acute preparation. However, a variety of… read more here.

Keywords: drg; stimulation; microstimulation; penetrating electrodes ... See more keywords
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Exercise-Induced Changes to the Macrophage Response in the Dorsal Root Ganglia Prevent Neuropathic Pain after Spinal Cord Injury.

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recommendations! Published in 2019 at "Journal of neurotrauma"

DOI: 10.1089/neu.2018.5819

Abstract: Spinal cord injury (SCI) induces neuropathic pain that is refractory to treatment. Central and peripheral immune responses to SCI play critical roles in pain development. Although immune responses in the dorsal horn have been implicated… read more here.

Keywords: drg; exercise; injury; pain ... See more keywords
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Upregulation of TRPV1 in spinal dorsal root ganglion by activating NGF‐TrkA pathway contributes to pelvic organ cross‐sensitisation in rats with experimental autoimmune prostatitis

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recommendations! Published in 2019 at "Andrologia"

DOI: 10.1111/and.13302

Abstract: Chronic prostatitis/chronic pelvic pain syndrome (CP⁄CPPS) is the prostate gland inflammation characterised as genitourinary pain in the pelvic region. The rat experimental autoimmune prostatitis (EAP) was achieved to mimic CP⁄CPPS. The expressions of transient receptor… read more here.

Keywords: drg; ngf trka; group; autoimmune prostatitis ... See more keywords

TNF-α/STAT3 pathway epigenetically upregulates Nav1.6 expression in DRG and contributes to neuropathic pain induced by L5-VRT

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recommendations! Published in 2019 at "Journal of Neuroinflammation"

DOI: 10.1186/s12974-019-1421-8

Abstract: BackgroundStudies showed that upregulation of Nav1.6 increased the neuronal excitability and participated in neuropathic pain in the dorsal root ganglion (DRG). However, the molecular mechanisms underlying Nav1.6 upregulation were not reported yet.MethodsThe paw withdrawal threshold… read more here.

Keywords: drg; stat3; scn8a; neuropathic pain ... See more keywords
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Optical recording reveals topological distribution of functionally classified colorectal afferent neurons in intact lumbosacral DRG

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recommendations! Published in 2019 at "Physiological Reports"

DOI: 10.14814/phy2.14097

Abstract: Neuromodulation as a non‐drug alternative for managing visceral pain in irritable bowel syndrome (IBS) may target sensitized afferents of distal colon and rectum (colorectum), especially their somata in the dorsal root ganglion (DRG). Developing selective… read more here.

Keywords: colorectal afferent; functionally classified; drg; topological distribution ... See more keywords