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   Articles with "drg neurons" as a keyword



Piezo1 Regulates Stiffness‐Dependent DRG Axon Regeneration via Modifying Cytoskeletal Dynamics

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202405705

Abstract: Despite medical interventions, the regenerative capacity of the peripheral nervous system is limited. Dorsal root ganglion (DRG) neurons possess the capacity to detect mechanical signals from their microenvironment, but the impact and mechanism by which… read more here.

Keywords: drg neurons; axon regrowth; axon regeneration; regeneration ... See more keywords

Distinct cellular expression and subcellular localization of Kv2 voltage‐gated K+ channel subtypes in dorsal root ganglion neurons conserved between mice and humans

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recommendations! Published in 2024 at "Journal of Comparative Neurology"

DOI: 10.1002/cne.25575

Abstract: The distinct organization of Kv2 voltage‐gated potassium channels on and near the cell body of brain neurons enables their regulation of action potentials and specialized membrane contact sites. Somatosensory neurons have a pseudounipolar morphology and… read more here.

Keywords: drg neurons; kv2 voltage; kv2; subcellular localization ... See more keywords
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Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons

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recommendations! Published in 2020 at "Journal of Neuroscience Research"

DOI: 10.1002/jnr.24688

Abstract: Axonal outgrowth is a fundamental process during the development of central (CNS) and peripheral (PNS) nervous system as well as in nerve regeneration and requires accurate axonal navigation and extension to the correct target. These… read more here.

Keywords: outgrowth; regeneration; drg neurons; dorsal root ... See more keywords

Functional Upregulation of TRPM3 Channels Contributes to Acute Pancreatitis-associated Pain and Inflammation

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recommendations! Published in 2024 at "Inflammation"

DOI: 10.1007/s10753-024-02138-8

Abstract: Transient receptor potential melastatin M3 (TRPM3) channels have been recognized as a pain transducer in dorsal root ganglion (DRG) neurons in recent years. TRPM3 activation initiates neurogenic inflammation and is required for the development of… read more here.

Keywords: drg neurons; pain; associated pain; inflammation ... See more keywords

Upregulation of N-type calcium channels in the soma of uninjured dorsal root ganglion neurons contributes to neuropathic pain by increasing neuronal excitability following peripheral nerve injury

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recommendations! Published in 2018 at "Brain, Behavior, and Immunity"

DOI: 10.1016/j.bbi.2018.04.016

Abstract: N-type voltage-gated calcium (Cav2.2) channels are expressed in the central terminals of dorsal root ganglion (DRG) neurons, and are critical for neurotransmitter release. Cav2.2 channels are also expressed in the soma of DRG neurons, where… read more here.

Keywords: drg neurons; drgs; dorsal root; upregulation ... See more keywords

Neuropathic pain in experimental autoimmune neuritis is associated with altered electrophysiological properties of nociceptive DRG neurons

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recommendations! Published in 2017 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2017.07.011

Abstract: Guillain-Barré syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy characterized by rapidly progressive paresis and sensory disturbances. Moderate to severe and often intractable neuropathic pain is a common symptom of GBS, but its underlying mechanisms are… read more here.

Keywords: gbs; drg neurons; pathology; neuropathic pain ... See more keywords

Activation of the capsaicin‐receptor TRPV1 by the acetaminophen metabolite N‐arachidonoylaminophenol results in cytotoxicity

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recommendations! Published in 2018 at "Life Sciences"

DOI: 10.1016/j.lfs.2017.12.024

Abstract: Aims: The anandamide reuptake inhibitor N‐arachidonoylaminophenol (AM404) and the reactive substance N‐acetyl‐p‐benzoquinone imine (NAPQI) are both metabolites of acetaminophen and may contribute to acetaminophen‐induced analgesia by acting at TRPV1 expressed in the peripheral or central… read more here.

Keywords: trpv1; drg neurons; cytotoxicity; receptor ... See more keywords

Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1

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recommendations! Published in 2021 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2021.101191

Abstract: Objective The distal dying-back of the longest nerve fibres is a hallmark of diabetic neuropathy, and impaired provision of energy in the form of adenosine triphosphate (ATP) may contribute to this neurodegenerative process. We hypothesised… read more here.

Keywords: neurons derived; glycolysis; atp; drg neurons ... See more keywords

The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel

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recommendations! Published in 2017 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2017.10.012

Abstract: &NA; Praziquantel is the most effective anthelminthic drug for the treatment of schistosomiasis, an infectious disease caused by the platyhelminth Schistosoma mansoni. While praziquantel is known to trigger calcium influx into schisostomes, followed by spastic… read more here.

Keywords: anthelminthic drug; drg neurons; drug; praziquantel ... See more keywords

20:4-NAPE induced changes of mechanical sensitivity and DRG neurons excitability are concentration dependent and mediated via NAPE-PLD

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-98567-y

Abstract: Alterations in the excitability of dorsal root ganglion (DRG) neurons are critical in the pathogenesis of acute and chronic pain. Neurotransmitter release from the terminals of DRG neurons is regulated by cannabinoid receptor 1 (CB1)… read more here.

Keywords: drg neurons; neurons excitability; concentration; nape ... See more keywords

Proneurotrophin-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons.

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recommendations! Published in 2025 at "EMBO reports"

DOI: 10.1038/s44319-025-00534-1

Abstract: Cancer patients undergoing treatment with antineoplastic drugs often experience chemotherapy-induced neuropathic pain (CINP), and therapeutic options for managing CINP are limited. Here, we show that systemic paclitaxel administration upregulates the expression of neurotrophin-3 (Nt3) mRNA… read more here.

Keywords: drg neurons; paclitaxel induced; pain; ccl2 ... See more keywords