Reelin activates the small GTPase TC10 and VAMP7 to promote neurite outgrowth and regeneration of dorsal root ganglia (DRG) neurons
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24688
Abstract: Axonal outgrowth is a fundamental process during the development of central (CNS) and peripheral (PNS) nervous system as well as in nerve regeneration and requires accurate axonal navigation and extension to the correct target. These… read more here.
Keywords: outgrowth; regeneration; drg neurons; dorsal root ... See more keywords
Upregulation of N-type calcium channels in the soma of uninjured dorsal root ganglion neurons contributes to neuropathic pain by increasing neuronal excitability following peripheral nerve injury
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.04.016
Abstract: N-type voltage-gated calcium (Cav2.2) channels are expressed in the central terminals of dorsal root ganglion (DRG) neurons, and are critical for neurotransmitter release. Cav2.2 channels are also expressed in the soma of DRG neurons, where… read more here.
Keywords: drg neurons; drgs; dorsal root; upregulation ... See more keywords
Neuropathic pain in experimental autoimmune neuritis is associated with altered electrophysiological properties of nociceptive DRG neurons
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.07.011
Abstract: Guillain-Barré syndrome (GBS) is an acute, immune-mediated polyradiculoneuropathy characterized by rapidly progressive paresis and sensory disturbances. Moderate to severe and often intractable neuropathic pain is a common symptom of GBS, but its underlying mechanisms are… read more here.
Keywords: gbs; drg neurons; pathology; neuropathic pain ... See more keywords
Activation of the capsaicin‐receptor TRPV1 by the acetaminophen metabolite N‐arachidonoylaminophenol results in cytotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.12.024
Abstract: Aims: The anandamide reuptake inhibitor N‐arachidonoylaminophenol (AM404) and the reactive substance N‐acetyl‐p‐benzoquinone imine (NAPQI) are both metabolites of acetaminophen and may contribute to acetaminophen‐induced analgesia by acting at TRPV1 expressed in the peripheral or central… read more here.
Keywords: trpv1; drg neurons; cytotoxicity; receptor ... See more keywords
Sensory neurons derived from diabetic rats exhibit deficits in functional glycolysis and ATP that are ameliorated by IGF-1
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101191
Abstract: Objective The distal dying-back of the longest nerve fibres is a hallmark of diabetic neuropathy, and impaired provision of energy in the form of adenosine triphosphate (ATP) may contribute to this neurodegenerative process. We hypothesised… read more here.
Keywords: neurons derived; glycolysis; atp; drg neurons ... See more keywords
The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.10.012
Abstract: &NA; Praziquantel is the most effective anthelminthic drug for the treatment of schistosomiasis, an infectious disease caused by the platyhelminth Schistosoma mansoni. While praziquantel is known to trigger calcium influx into schisostomes, followed by spastic… read more here.
Keywords: anthelminthic drug; drg neurons; drug; praziquantel ... See more keywords
Paclitaxel-induced painful neuropathy is associated with changes in mitochondrial bioenergetics, glycolysis, and an energy deficit in dorsal root ganglia neurons
Sign Up to like & getrecommendations! Published in 2017 at "Pain"
DOI: 10.1097/j.pain.0000000000000939
Abstract: Abstract Painful neuropathy is the major dose-limiting side effect of paclitaxel chemotherapy. Mitochondrial dysfunction and adenosine triphosphate (ATP) deficit have previously been shown in peripheral nerves of paclitaxel-treated rats, but the effects of paclitaxel in… read more here.
Keywords: drg neurons; paclitaxel; dorsal root; deficit ... See more keywords
Pioglitazone, a PPAR&ggr; agonist, reduces cisplatin-evoked neuropathic pain by protecting against oxidative stress
Sign Up to like & getrecommendations! Published in 2019 at "PAIN"
DOI: 10.1097/j.pain.0000000000001448
Abstract: Abstract Painful peripheral neuropathy is a dose-limiting side effect of cisplatin treatment. Using a murine model of cisplatin-induced hyperalgesia, we determined whether a PPAR&ggr; synthetic agonist, pioglitazone, attenuated the development of neuropathic pain and identified… read more here.
Keywords: pioglitazone; drg neurons; cisplatin evoked; ppar ggr ... See more keywords
Anoctamin 1/TMEM16A in pruritoceptors is essential for Mas-related G protein receptor-dependent itch.
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002611
Abstract: ABSTRACT Itch is an unpleasant sensation that evokes a desire to scratch. Pathologic conditions such as allergy or atopic dermatitis produce severe itching sensation. Mas-related G protein receptors (Mrgprs) are receptors for many endogenous pruritogens.… read more here.
Keywords: related protein; drg neurons; dependent itch; itch ... See more keywords
Neurochemical characterization of mouse dorsal root ganglion neurons expressing organic cation transporter 2
Sign Up to like & getrecommendations! Published in 2020 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001416
Abstract: Organic cation transporters (OCTs) are poly-specific carriers for endogenous and exogenous cationic compounds. These are widely distributed in the nervous system and mediate neuronal activities. As antineoplastic cationic drugs accumulate in the dorsal root ganglion… read more here.
Keywords: root ganglion; organic cation; dorsal root; dorsal ... See more keywords
Fibroblast Growth Factor Homologous Factor 2 attenuates excitability of DRG neurons.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00361.2022
Abstract: Fibroblast Growth Factor Homologous Factors (FHFs) are cytosolic members of the of the FGF proteins. Four members of this subfamily (FHF1-4) are differentially expressed in multiple tissues in an isoform-dependent manner. Mutations in FHF proteins… read more here.
Keywords: drg neurons; factor; excitability; growth factor ... See more keywords