Upregulation of N-type calcium channels in the soma of uninjured dorsal root ganglion neurons contributes to neuropathic pain by increasing neuronal excitability following peripheral nerve injury
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.04.016
Abstract: N-type voltage-gated calcium (Cav2.2) channels are expressed in the central terminals of dorsal root ganglion (DRG) neurons, and are critical for neurotransmitter release. Cav2.2 channels are also expressed in the soma of DRG neurons, where… read more here.
Keywords: drg neurons; drgs; dorsal root; upregulation ... See more keywords
Phospholipase Cβ3 Expressed in Mouse DRGs is Involved in Inflammatory and Postoperative Pain
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pain Research"
DOI: 10.2147/jpr.s280565
Abstract: Background Previous studies suggested that phospholipase Cβ3 (PLCβ3), which is a common downstream component in the signaling cascade, plays an important role in peripheral mechanisms of perception including nociception. However, detailed profiles of PLCβ3-expressing dorsal… read more here.
Keywords: plc; pain; inflammatory postoperative; postoperative pain ... See more keywords
Thoracic dorsal root ganglion stimulation reduces acute myocardial ischemia induced ventricular arrhythmias
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1091230
Abstract: Background Dorsal root ganglion stimulation (DRGS) may serve as a novel neuromodulation strategy to reduce cardiac sympathoexcitation and ventricular excitability. Objective In this pre-clinical study, we investigated the effectiveness of DRGS on reducing ventricular arrhythmias… read more here.
Keywords: ischemia; myocardial ischemia; drgs; stimulation ... See more keywords