Dried plasma spot-based liquid chromatography-tandem mass spectrometry for the quantification of methotrexate in human plasma and its application in therapeutic drug monitoring.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202100700
Abstract: Methotrexate, a folic acid antitumor drug, is widely used to treat childhood acute lymphoblastic leukemia. Therapeutic drug monitoring is crucial for adjusting the dosage of methotrexate according to its plasma concentration and reducing adverse effects.… read more here.
Keywords: spot; plasma spot; methotrexate; dried plasma ... See more keywords
Dried plasma spots for therapeutic monitoring of amikacin: Validation of an UHPLC-MS/MS assay and pharmacokinetic application.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113201
Abstract: Amikacin (AMI) is an aminoglycoside antibiotic widely used in the treatment of severe infections caused by multi-resistant bacteria, with established exposition targets in therapeutic drug monitoring (TDM). The usual specimen for AMI concentration measurement is… read more here.
Keywords: dried plasma; plasma spots; spots therapeutic; ami ... See more keywords
Dried plasma spot assay for sunitinib and its active metabolite by high performance liquid chromatography tandem mass spectrometry: 547P
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdx678.004
Abstract: plasma protein-A (PAPP-A) is a metalloproteinase that cleaves insulin-like growth factor 1 (IGF-1) from a circulating complex formed with insulin-like growth factor binding protein 4 (IGFBP4). Increased bioavailability of IGF1 subsequently impacts on tumour biology.… read more here.
Keywords: active metabolite; dried plasma; sunitinib active; plasma spot ... See more keywords
Novel blood derived hemostatic agents for bleeding therapy and prophylaxis
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000737
Abstract: Purpose of review Hemorrhage is a major cause of preventable death in trauma and cancer. Trauma induced coagulopathy and cancer-associated endotheliopathy remain major therapeutic challenges. Early, aggressive administration of blood-derived products with hypothesized increased clotting… read more here.
Keywords: freeze dried; prophylaxis; dried plasma; novel blood ... See more keywords
Diagnostic accuracy of dried plasma spot specimens for HIV-1 viral load testing: a systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of acquired immune deficiency syndromes"
DOI: 10.1097/qai.0000000000002855
Abstract: BACKGROUND Dried plasma spot specimens may be a viable alternative to traditional liquid plasma in field settings, but the diagnostic accuracy is not well understood. METHODS Standard databases (PubMed and Medline), conferences, and grey literature… read more here.
Keywords: dried plasma; diagnostic accuracy; viral load; spot specimens ... See more keywords
Freeze‐dried plasma stability under prehospital field conditions
Sign Up to like & getrecommendations! Published in 2019 at "Transfusion"
DOI: 10.1111/trf.15533
Abstract: This study evaluated the effect of routine, uncontrolled, Israeli field storage conditions on the stability and efficacy of Lyo‐Plas N freeze‐dried plasma (FDP). We evaluated clotting factors V, VIII, and XI; proteins S and C;… read more here.
Keywords: dried plasma; plasma stability; field; freeze dried ... See more keywords
Ex vivo hemostatic and immuno‐inflammatory profiles of freeze‐dried plasma
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DOI: 10.1111/trf.16502
Abstract: Hemorrhage is a leading cause of preventable death in civilian and military trauma. Freeze‐dried plasma is promising for hemostatic resuscitation in remote prehospital settings, given its potential benefits in reducing blood loss and mortality, long… read more here.
Keywords: vivo hemostatic; dried plasma; immuno inflammatory; inflammatory profiles ... See more keywords
Spray‐dried plasma: A post‐traumatic blood “bridge” for life‐saving resuscitation
Sign Up to like & getrecommendations! Published in 2021 at "Transfusion"
DOI: 10.1111/trf.16536
Abstract: Massive bleeding remains a major source of morbidity and mortality worldwide. Recent studies have shed light on the pathophysiology of traumatic‐induced coagulopathy and the central role of endotheliopathy. Transfusion therapy has changed dramatically in the… read more here.
Keywords: post traumatic; plasma post; dried plasma; blood ... See more keywords
Freeze‐dried plasma: From damage control resuscitation to coronavirus disease 2019 therapy
Sign Up to like & getrecommendations! Published in 2022 at "Transfusion"
DOI: 10.1111/trf.16947
Abstract: Freeze‐dried plasma (FDP) is a promising blood component for prehospital resuscitation given its logistic advantages over fresh frozen plasma (FFP). COVID‐19 convalescent (CC) plasma has been used to treat coronavirus disease 2019 (COVID‐19) patients, and… read more here.
Keywords: freeze dried; coronavirus disease; dried plasma; disease 2019 ... See more keywords
Dried Plasma Spot Based LC–MS/MS Method for Monitoring of Meropenem in the Blood of Treated Patients
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27061991
Abstract: Meropenem (MER) is widely used to treat complicated and serious infections. Therapeutic drug monitoring (TDM) provides a valid clinical tool to avoid suboptimal concentrations and dose–related adverse reactions. However, TDM seems to face challenges since… read more here.
Keywords: plasma spot; dried plasma; plasma; method ... See more keywords
Quantification of Zonisamide in Dried Blood Spots and Dried Plasma Spots by UPLC–MS/MS: Application to Clinical Practice
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154899
Abstract: In this research, a UHPLC–MS/MS method was developed and validated for the determination of zonisamide in dried plasma spots (DPS) and dried blood spots (DBS). Detection of zonisamide and internal standard, 1-(2,3-dichlorphenyl)piperazine, was carried out… read more here.
Keywords: zonisamide; dried plasma; dried blood; blood ... See more keywords