Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1.
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DOI: 10.1016/j.ejmech.2017.07.078
Abstract: An abnormal increase in glucocorticoid levels is responsible for pathological disorders affecting different organs and systems, and the selective inhibition of appropriate steroidogenic enzymes represents a validated strategy to restore their physiological levels. In continuing… read more here.
Keywords: coordinating group; drifting heme; inhibition; cyp11b1 ... See more keywords