PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2
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DOI: 10.1038/onc.2016.213
Abstract: The plasma membrane-associated tyrosine phosphatase PTPRO is frequently transcriptionally repressed in cancers and signifies poor prognosis of breast cancer patients. In this study, deletion of Ptpro in MMTV-Erbb2 transgenic mice dramatically shortened the mammary tumor… read more here.
Keywords: driven breast; erbb2; erbb2 driven; breast cancer ... See more keywords