Stressing Myc-driven cancer out
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aar7535
Abstract: Myc-driven cancers can be targeted with the IRE1α inhibitor. Myc-driven cancers can be targeted with the IRE1α inhibitor. read more here.
Keywords: medicine; driven cancer; stressing myc; myc driven ... See more keywords
Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0276579
Abstract: Metabolic reprogramming is now considered a hallmark of cancer cells. KRas-driven cancer cells use glutaminolysis to generate the tricarboxylic acid cycle intermediate α-ketoglutarate via a transamination reaction between glutamate and oxaloacetate. We reported previously that… read more here.
Keywords: cancer cells; atp citrate; citrate lyase; driven cancer ... See more keywords
miRacle of microRNA-Driven Cancer Nanotherapeutics
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DOI: 10.3390/cancers14153818
Abstract: Simple Summary The discovery of microRNAs has revolutionized the world of science and opened up new opportunities in cancer treatment. miRNA dysregulation plays a crucial role in carcinogenesis processes, such as invasion, metastasis, and angiogenesis,… read more here.
Keywords: microrna driven; driven cancer; miracle microrna; tumor ... See more keywords
A Look Inside of the Complex Pathogenesis of B-RAF(V600E)-Driven Cancer
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DOI: 10.7150/thno.20460
Abstract: Cancer is a very complex disease, where cell alterations (i.e. gene mutations, dysregulated signaling pathway(s) and epigenetic modifications) contribute to its development and progression. Elucidating the connections among these cell modifications is a critical challenge,… read more here.
Keywords: cancer; v600e driven; driven cancer; raf v600e ... See more keywords
Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.67300
Abstract: Cancer immunotherapy has made tremendous clinical progress in advanced-stage malignancies. However, patients with various tumors exhibit a low response rate to immunotherapy because of a powerful immunosuppressive tumor microenvironment (TME) and insufficient immunogenicity of tumors.… read more here.
Keywords: driven cancer; immunotherapy; pdt driven; cancer immunotherapy ... See more keywords