Identification of potential inhibitors, conformational dynamics, and mechanistic insights into mutant Kirsten rat sarcoma virus (G13D) driven cancers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30305
Abstract: The mutations at the hotspot region of K‐Ras result in the progression of cancer types. Our study aimed to explore the small molecule inhibitors against the G13D mutant K‐Ras model with anti‐cancerous activity from food… read more here.
Keywords: potential inhibitors; identification potential; driven cancers; conformational dynamics ... See more keywords
Photodynamic therapy for ras-driven cancers: targeting G-quadruplex RNA structures with bifunctional alkyl-modified porphyrins.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01577
Abstract: Designing small molecules capable to break down G4 structures in mRNA (RG4s) offers an interesting approach to cancer therapy. Here, we have studied cationic porphyrins (CPs) bearing an alkyl chain up to 12 carbons, as… read more here.
Keywords: photodynamic therapy; alkyl cps; therapy; therapy ras ... See more keywords
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
Sign Up to like & getrecommendations! Published in 2019 at "Nature medicine"
DOI: 10.1038/s41591-019-0367-9
Abstract: Pancreatic ductal adenocarcinoma (PDA) was responsible for ~ 44,000 deaths in the United States in 2018 and is the epitome of a recalcitrant cancer driven by a pharmacologically intractable oncoprotein, KRAS1–4. Downstream of KRAS, the RAF→MEK→ERK… read more here.
Keywords: mek erk; inhibition; driven cancers; ras driven ... See more keywords
Abstract 3200: Targeting PHF5A for the treatment of glioblastoma and other Myc-driven cancers
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3200
Abstract: Glioblastoma multiforme (GBM) is one of the most aggressive and invasive types of brain cancer, but targeted treatment options remain elusive. The standard of care (surgery chemotherapy and radiation) falls far short of where it… read more here.
Keywords: glioblastoma myc; myc driven; targeting phf5a; phf5a ... See more keywords
Abstract 4034: A potent and highly selective irreversible HER2 inhibitor for treating HER2-driven cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4034
Abstract: HER2 amplification and mutations occur frequently in multiple human cancers, including breast, ovarian, gastric and lung cancers. Despite HER2 being one of the earliest oncogenic drivers discovered, HER2 inhibitors have had limited clinical success compared… read more here.
Keywords: ent; her2; inhibitor; driven cancers ... See more keywords
Abstract IA12: Developing combinatorial therapies for KRAS-driven cancers
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-ia12
Abstract: The RAS pathway is one of the most commonly deregulated pathways in human cancer. Approximately 30% of all tumors harbor activating mutations in either KRAS, NRAS or HRAS, and even more possess alterations in other… read more here.
Keywords: abstract ia12; combinatorial therapies; driven cancers; developing combinatorial ... See more keywords
Abstract IA25: Systematic interrogation of KRAS function
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras23-ia25
Abstract: Oncogenic mutations of KRAS occur frequently in pancreas, lung and colon cancers. Recent efforts to target particular KRAS alleles or RAS effector pathways has led to clinical responses but resistance to therapy limits the effectiveness… read more here.
Keywords: systematic interrogation; abstract ia25; kras function; driven cancers ... See more keywords
KRAS-Driven Cancers Are Dependent on METTL13-Mediated eEF1A Methylation.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2019-005
Abstract: Methylation of eEF1A by METTL13 is required for KRAS-driven pancreatic and lung tumorigenesis. read more here.
Keywords: driven cancers; mettl13 mediated; cancers dependent; methylation ... See more keywords
Deciphering Steroid Receptor Crosstalk in Hormone-Driven Cancers
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2018-00831
Abstract: Steroid hormone receptors (SRs) have a multitude of functions in human biology and disease progression. The SR family of related ligand-activated transcription factors includes androgen, estrogen, glucocorticoid, mineralocorticoid, and progesterone receptors. Antiestrogen or estrogen receptor… read more here.
Keywords: hormone; hormone driven; crosstalk; receptor ... See more keywords
How Does Epstein–Barr Virus Interact With Other Microbiomes in EBV-Driven Cancers?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.852066
Abstract: The commensal microbiome refers to a large spectrum of microorganisms which mainly consists of viruses and bacteria, as well as some other components such as protozoa and fungi. Epstein–Barr virus (EBV) is considered as a… read more here.
Keywords: epstein barr; driven cancers; commensal microbiome; ebv driven ... See more keywords
Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.01049
Abstract: Cellular plasticity, a feature associated with epithelial-to-mesenchymal transition (EMT), contributes to tumor cell survival, migration, invasion, and therapy resistance. Phenotypic plasticity of the epithelium is a critical feature in multiple phases of human cancer in… read more here.
Keywords: behind wheel; driven cancers; cellular plasticity; kras driven ... See more keywords