Molecular dynamics-driven drug discovery: leaping forward with confidence.
Sign Up to like & getrecommendations! Published in 2017 at "Drug discovery today"
DOI: 10.1016/j.drudis.2016.11.001
Abstract: Given the significant time and financial costs of developing a commercial drug, it remains important to constantly reform the drug discovery pipeline with novel technologies that can narrow the candidates down to the most promising… read more here.
Keywords: molecular dynamics; drug; discovery; driven drug ... See more keywords
A self-powered battery-driven drug delivery device that can function as a micromotor and galvanically actuate localized payload release
Sign Up to like & getrecommendations! Published in 2019 at "Nano Energy"
DOI: 10.1016/j.nanoen.2019.104120
Abstract: Abstract Most drug delivery vehicles lack thrust that propels them to disease sites for payload delivery. Herein, a microrod comprising a zinc (Zn) core and a positively-charged poly(3,4-ethylenedioxythiophene) (PEDOT+) shell incorporating an anionic model drug,… read more here.
Keywords: drug delivery; delivery; drug; battery driven ... See more keywords
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01863
Abstract: The acetylcholinesterase (AChE) inhibitors remain key therapeutic drugs for the treatment of Alzheimer's disease (AD). However, the low-safety window limits their maximum therapeutic benefits. Here, a novel kinetics-driven drug design strategy was employed to discover… read more here.
Keywords: acetylcholinesterase; drug design; drug; driven drug ... See more keywords
Integrating metabolomics, bionics, and culturomics to study probiotics-driven drug metabolism
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1047863
Abstract: Many drugs have been shown to be metabolized by the human gut microbiome, but probiotic-driven drug-metabolizing capacity is rarely explored. Here, we developed an integrated metabolomics, culturomics, and bionics framework for systematically studying probiotics-driven drug… read more here.
Keywords: drug metabolism; gut microbiome; driven drug; drug ... See more keywords