Virus-driven Inflammation Is Associated With the Development of bNAbs in Spontaneous Controllers of HIV
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Infectious Diseases"
DOI: 10.1093/cid/cix057
Abstract: Background Understanding the mechanism(s) by which broadly neutralizing antibodies (bNAbs) emerge naturally following infection is crucial for the development of a protective vaccine against human immunodeficiency virus (HIV). Although previous studies have implicated high viremia… read more here.
Keywords: virus driven; development bnabs; controllers hiv; driven inflammation ... See more keywords
Bacterial-driven inflammation and mutant BRAF expression combine to promote murine colon tumorigenesis that is sensitive to immune checkpoint therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-0770
Abstract: Colorectal cancer (CRC) is multi-faceted with subtypes defined by genetic, histological, and immunologic features which are potentially influenced by inflammation, mutagens, and/or microbiota. CRCs with activating mutations in BRAF are associated with distinct clinical characteristics… read more here.
Keywords: inflammation mutant; murine; bacterial driven; colon ... See more keywords
Aryl Hydrocarbon Receptor Agonism Antagonizes the Hypoxia-driven Inflammation in Cystic Fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2022-0196oc
Abstract: Hypoxia contributes to the exaggerated yet ineffective airway inflammation that fails to oppose infections in cystic fibrosis (CF). However, the potential for impairment of essential immune functions by the hypoxia-inducible factor (HIF)-1α inhibition demands for… read more here.
Keywords: inflammation; driven inflammation; hypoxia driven; hypoxia ... See more keywords
Serum periostin does not reflect type 2-driven inflammation in COPD
Sign Up to like & getrecommendations! Published in 2018 at "Respiratory Research"
DOI: 10.1186/s12931-018-0818-8
Abstract: Although Th2 driven inflammation is present in COPD, it is not clearly elucidated which COPD patients are affected. Since periostin is associated with Th2 driven inflammation and inhaled corticosteroid (ICS)-response in asthma, it could function… read more here.
Keywords: copd; driven inflammation; periostin; serum periostin ... See more keywords
Who and how, DNA sensors in NETs-driven inflammation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1190177
Abstract: During infections, neutrophil extracellular traps act like a meshwork of molecules that captures microbes. In contrast, during sterile inflammation the presence of NETs is usually associated with tissue damage and uncontrolled inflammation. In this context,… read more here.
Keywords: inflammation; sensors nets; dna sensors; driven inflammation ... See more keywords
Macrophage-Driven Inflammation in Metabolic Osteoarthritis: Implications for Biomarker and Therapy Development
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076112
Abstract: Osteoarthritis (OA) is a common and debilitating joint disorder that leads to progressive joint breakdown and loss of articular cartilage. Accompanied by a state of low-grade inflammation, its etiology extends beyond that of a wear-and-tear… read more here.
Keywords: macrophage driven; driven inflammation; osteoarthritis; macrophage ... See more keywords