ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression
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DOI: 10.1038/s41598-019-56277-2
Abstract: Aberrant differentiation, driven by activation of normally silent tissue-specific genes, results in a switch of cell identity and often leads to cancer progression. The underlying genetic and epigenetic events are largely unexplored. Here, we report… read more here.
Keywords: lung adenocarcinoma; driven lung; onecut2 overexpression; cancer ... See more keywords
Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis
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DOI: 10.1158/0008-5472.can-21-3214
Abstract: Loss of RBMS3 cooperates with BRAFV600E to induce lung tumorigenesis, providing a deeper understanding of the molecular mechanisms underlying mutant BRAF-driven lung cancer and potential strategies to more effectively target this disease. read more here.
Keywords: transposon mutagenesis; mutagenesis reveals; driven lung; lung tumorigenesis ... See more keywords
BRAFV600E-Driven Lung Adenocarcinoma Requires Copper to Sustain Autophagic Signaling and Processing
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DOI: 10.1158/1541-7786.mcr-21-0250
Abstract: Abstract The transition metal copper (Cu) is an essential micronutrient required for development and proliferation, but the molecular mechanisms by which Cu contributes to these processes is not fully understood. Although traditionally studied as a… read more here.
Keywords: autophagic signaling; brafv600e driven; lung adenocarcinoma; driven lung ... See more keywords
Selective targeting of KRAS-driven lung tumorigenesis via unresolved ER stress
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DOI: 10.1172/jci.insight.137876
Abstract: Lung cancer with oncogenic KRAS makes up a significant proportion of lung cancers and is accompanied by a poor prognosis. Recent advances in understanding the molecular pathogenesis of lung cancer with oncogenic KRAS have enabled… read more here.
Keywords: driven lung; lung cancer; kras driven; lung tumorigenesis ... See more keywords