The X-linked helicase DDX3X is required for lymphoid differentiation and MYC-driven lymphomagenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-2454
Abstract: The X-linked gene DDX3X encodes an RNA helicase that is mutated at high frequencies in several types of human B-cell lymphoma. Females have two active DDX3X alleles and males carry a DDX3Y homolog on the… read more here.
Keywords: lymphomagenesis; driven lymphomagenesis; helicase ddx3x; ddx3x ... See more keywords
Withaferin A inhibits EBV-driven lymphomagenesis through multiple mechanisms, including EBNA1 degradation.
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood.2025029771
Abstract: Epstein-Barr virus (EBV) infects over 90% of the global population and drives multiple aggressive B cell malignancies, including Burkitt lymphoma (BL), diffuse large B cell lymphoma (DLBCL), and Hodgkin lymphoma. Standard chemoimmunotherapy regimens can be… read more here.
Keywords: survival; degradation; driven lymphomagenesis; cell ... See more keywords