ATOH8 binds SMAD3 to induce cellular senescence and prevent Ras-driven malignant transformation.
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DOI: 10.1073/pnas.2208927120
Abstract: The process of oncogene-induced senescence (OIS) and the conversion between OIS and malignant transformation during carcinogenesis is poorly understood. Here, we show that following overactivation of oncogene Ras in lung epithelial cells, high-level transforming growth… read more here.
Keywords: ras driven; senescence; driven malignant; cellular senescence ... See more keywords