Genomic landscape and chronological reconstruction of driver events in multiple myeloma
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DOI: 10.1038/s41467-019-11680-1
Abstract: The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using sequences from 67 MM genomes serially collected from 30 patients… read more here.
Keywords: driver events; events multiple; multiple myeloma; landscape chronological ... See more keywords
Molecular profiling of driver events in metastatic uveal melanoma
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DOI: 10.1038/s41467-020-15606-0
Abstract: Metastatic uveal melanoma is less well understood than its primary counterpart, has a distinct biology compared to skin melanoma, and lacks effective treatments. Here we genomically profile metastatic tumors and infiltrating lymphocytes. BAP1 alterations are… read more here.
Keywords: melanoma; molecular profiling; uveal melanoma; metastatic uveal ... See more keywords
DNA methylation variation along the cancer epigenome and the identification of novel epigenetic driver events
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DOI: 10.1093/nar/gkab1167
Abstract: Abstract While large-scale studies applying various statistical approaches have identified hundreds of mutated driver genes across various cancer types, the contribution of epigenetic changes to cancer remains more enigmatic. This is partly due to the… read more here.
Keywords: cancer; epigenetic driver; driver events; dna methylation ... See more keywords
Cancer types with high numbers of driver events are largely preventable
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.12672
Abstract: There is a long-standing debate on whether cancer is predominantly driven by extrinsic risk factors such as smoking, or by intrinsic processes such as errors in DNA replication. We have previously shown that the number… read more here.
Keywords: types high; driver events; cancer types; risk factors ... See more keywords