Methylation of N6 adenosine‐related long noncoding RNA: effects on prognosis and treatment in ‘driver‐gene‐negative’ lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13323
Abstract: The improvement of treatment for patients with ‘driver‐gene‐negative’ lung adenocarcinoma (LUAD) remains a critical problem to be solved. We aimed to explore the role of methylation of N6 adenosine (m6A)‐related long noncoding RNA (lncRNA) in… read more here.
Keywords: negative lung; gene negative; driver gene; rna ... See more keywords
Transcriptomic heterogeneity of driver gene mutations reveals novel mutual exclusivity and improves exploration of functional associations
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.4039
Abstract: Lung adenocarcinoma (LUAD), as the most common subtype of lung cancer, is the leading cause of cancer deaths in the world. The accumulation of driver gene mutations enables cancer cells to gradually acquire growth advantage.… read more here.
Keywords: cancer; transcriptomic heterogeneity; driver gene; gene mutations ... See more keywords
A cross‐sectional study of the FDA approved indications and supporting pivotal trials of small‐molecular kinase inhibitors in cancer therapies with the biomarker of cancer driver gene
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34222
Abstract: Cancer precision medicine with biomarker of cancer driver gene (CDG) has been achieved by many small‐molecular kinase inhibitors (SMKIs) approved by the US Food and Drug Administration (FDA). Publicly available FDA documents were collected for… read more here.
Keywords: driver gene; biomarker; small molecular; biomarker cancer ... See more keywords
Pulmonary toxicity in driver gene positive non-small cell lung cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2022.2085964
Abstract: Abstract Molecular targeted therapy significantly improved the therapeutic efficacy in non-small cell lung cancer (NSCLC) patients with driver gene mutations but also with new toxicity profiles. Although most patients treated with these drugs developed relatively… read more here.
Keywords: driver gene; therapy; toxicity; lung ... See more keywords
Driver Gene Mutations and Epigenetics in Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Surgery"
DOI: 10.1097/sla.0000000000003393
Abstract: OBJECTIVE The majority of patients with colorectal cancer are diagnosed with locally advanced and/or disseminated disease, and treatment options include surgery in combination with cytotoxic chemotherapy regimens, biologics, and/or radiotherapy. Thus, colorectal cancer remains a… read more here.
Keywords: mutations epigenetics; cancer; driver gene; colorectal cancer ... See more keywords
The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.24.497463
Abstract: Meiotic drivers are selfish elements that bias their own transmission into more than half of the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought to exist for relatively short evolutionary timespans because… read more here.
Keywords: driver gene; 100 million; gene family; million years ... See more keywords
Clinical and molecular characteristics of forty Chinese children with essential thrombocythemia: A single‐center, retrospective analysis
Sign Up to like & getrecommendations! Published in 2023 at "British Journal of Haematology"
DOI: 10.1111/bjh.18646
Abstract: Due to the infrequency of essential thrombocythemia (ET) in children, little is known about its pathophysiological mechanism. To learn about the clinical and molecular features of Chinese children with ET, we retrospectively analysed 40 children… read more here.
Keywords: gene mutations; clinical molecular; essential thrombocythemia; driver gene ... See more keywords
PO-461 A transcriptomic and molecular approach to uncovering achaete-scute complex homolog 2 (ASCL2) as a potential novel driver gene in breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.968
Abstract: Introduction Breast cancer is highly heterogeneous and despite ongoing advancements in diagnostics and targeted therapeutics, incidence and mortality continues to rise. Thus, there is a need for greater characterisation of driver genes to understand their… read more here.
Keywords: gene; driver gene; breast; breast cancer ... See more keywords
FBXW7 is a biologically validated cancer driver gene for CLL.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2018-12-891507
Abstract: F-box and WD40 repeat domain containing-7 (FBXW7) is one of the statistically defined candidate cancer driver genes for chronic lymphocytic leukemia (CLL). In this issue of Blood, Close et al describe functional genomic experiments that… read more here.
Keywords: gene cll; cancer driver; driver gene; driver ... See more keywords
Rechallenge with erlotinib in osimertinib-resistant lung adenocarcinoma mediated by driver gene loss: a case report.
Sign Up to like & getrecommendations! Published in 2020 at "Translational lung cancer research"
DOI: 10.21037/tlcr.2020.01.10
Abstract: The efficacy and safety of osimertinib have been demonstrated in several clinical trials; however, acquired resistance is an inevitable problem associated with most targeted drugs. Based on previous findings, the mechanism of osimertinib resistance is… read more here.
Keywords: driver gene; resistance; gene loss; mediated driver ... See more keywords
Driver Gene Alterations in Malignant Progression of Gastric Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.920207
Abstract: The identification of driver genes is of great importance in modern medical research. It is also an essential factor in the development of individualization and has a positive effect on understanding the causes of cancer.… read more here.
Keywords: driver; driver gene; gastric cancer; driver genes ... See more keywords