Driver mutations of young lung adenocarcinoma patients with malignant pleural effusion
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.1002/gcc.22647
Abstract: Young lung cancer patients have several distinct characteristics. However, there are limited epidemiological data of genetic abnormalities in this population. We conducted a prospective cohort study to delineate the various oncogenic driver mutations of lung… read more here.
Keywords: lung adenocarcinoma; aged years; driver mutations; patients aged ... See more keywords
No evidence that HLA genotype influences the driver mutations that occur in cancer patients
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-03028-w
Abstract: The major histocompatibility (MHC) molecules are capable of presenting neoantigens resulting from somatic mutations on cell surfaces, potentially directing immune responses against cancer. This led to the hypothesis that cancer driver mutations may occur in… read more here.
Keywords: genotype; mutations occur; mhc; cancer ... See more keywords
Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.12.027
Abstract: A comprehensive catalog of cancer driver mutations is essential for understanding tumorigenesis and developing therapies. Exome-sequencing studies have mapped many protein-coding drivers, yet few non-coding drivers are known because genome-wide discovery is challenging. We developed… read more here.
Keywords: cancer driver; long range; cancer; driver mutations ... See more keywords
SOMATIC DRIVER MUTATIONS IN ORAL AND SINONASAL MUCOSAL MELANOMA. A REFERRAL CENTRE EXPERIENCE IN MEXICO CITY
Sign Up to like & getrecommendations! Published in 2019 at "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"
DOI: 10.1016/j.oooo.2019.02.199
Abstract: Objective Oral and sinonasal mucosal melanomas (OSNMM) are aggressive tumors with low survival and few therapeutic alternatives. The aim of this study was to describe the prevalence of mutations in NRASQ61K, BRAFV600E, CKITL576P, K642E, MITFE318K… read more here.
Keywords: mexico city; oral sinonasal; pathology; somatic driver ... See more keywords
Genomic Characterization of High-Count MBL Cases Indicates that Early Detection of Driver Mutations and Subclonal Expansion are Predictors of Adverse Clinical Outcome
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2016.172
Abstract: High-count monoclonal B-cell lymphocytosis (MBL) is an asymptomatic expansion of clonal B cells in the peripheral blood without other manifestations of chronic lymphocytic leukemia (CLL). Yearly, 1% of MBLs evolve to CLL requiring therapy; thus… read more here.
Keywords: driver; high count; expansion; mbl ... See more keywords
Life histories of myeloproliferative neoplasms inferred from phylogenies
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1038/s41586-021-04312-6
Abstract: Mutations in cancer-associated genes drive tumour outgrowth, but our knowledge of the timing of driver mutations and subsequent clonal dynamics is limited 1 – 3 . Here, using whole-genome sequencing of 1,013 clonal haematopoietic colonies… read more here.
Keywords: jak2 v617f; myeloproliferative neoplasms; driver mutations; acquisition ... See more keywords
Systematic analysis of alterations in the ubiquitin proteolysis system reveals its contribution to driver mutations in cancer
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Cancer"
DOI: 10.1038/s43018-019-0001-2
Abstract: E3 ligases and degrons, the sequences they recognize in target proteins, are key parts of the ubiquitin-mediated proteolysis system. There are several examples of alterations of these two components of the system that have a… read more here.
Keywords: cancer; driver mutations; system; proteolysis system ... See more keywords
Identification of outcome-related driver mutations in cancer using conditional co-occurrence distributions
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43350
Abstract: Previous methods proposed for the detection of cancer driver mutations have been based on the estimation of background mutation rate, impact on protein function, or network influence. In this paper, we instead focus on those… read more here.
Keywords: related driver; outcome related; identification outcome; cancer ... See more keywords
Frequency of JAK2V617F, MPL and CALR driver mutations and associated clinical characteristics in a Norwegian patient cohort with myeloproliferative neoplasms
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2022.2150984
Abstract: Abstract Myeloproliferative neoplasms are hematological disorders characterized by increased production in one or more myeloid cell lines, associated with driver mutations in JAK2-, MPL- and CALR-genes. The aims of this study were to investigate the… read more here.
Keywords: calr; jak2v617f; patient cohort; driver mutations ... See more keywords
An evolution-based machine learning to identify cancer type-specific driver mutations
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac593
Abstract: Identifying cancer type-specific driver mutations is crucial for illuminating distinct pathologic mechanisms across various tumors and providing opportunities of patient-specific treatment. However, although many computational methods were developed to predict driver mutations in a type-specific… read more here.
Keywords: cancer; specific driver; type specific; cancer type ... See more keywords
Dr.Nod: computational framework for discovery of regulatory non-coding drivers in tissue-matched distal regulatory elements
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1251
Abstract: Abstract The discovery of cancer driver mutations is a fundamental goal in cancer research. While many cancer driver mutations have been discovered in the protein-coding genome, research into potential cancer drivers in the non-coding regions… read more here.
Keywords: cancer; tissue matched; framework; driver mutations ... See more keywords