Chromosomal instability drives convergent and divergent evolution toward advantageous inherited traits in mammalian CHO bioproduction lineages
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DOI: 10.1016/j.isci.2022.104074
Abstract: Summary Genetic instability of Chinese hamster ovary (CHO) cells is implicated in production inconsistency through poorly defined mechanisms. Using a multi-omics approach, we analyzed the variations of CHO lineages derived from CHO-K1 cells. We identify… read more here.
Keywords: instability drives; drives convergent; convergent divergent; chromosomal instability ... See more keywords