Dronedarone (a multichannel blocker) enhances the anticonvulsant potency of lamotrigine, but not that of lacosamide, pregabalin and topiramate in the tonic-clonic seizure model in mice
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2019.04.007
Abstract: Accumulating experimental evidence indicates that some recently licensed antiarrhythmic drugs, including dronedarone (a multichannel blocker) play a crucial role in initiation of seizures in both, in vivo and in vitro studies. Some of these antiarrhythmic… read more here.
Keywords: anticonvulsant potency; dronedarone; pregabalin topiramate; mice ... See more keywords
Dronedarone versus sotalol in patients with atrial fibrillation: A systematic literature review and network meta-analysis.
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DOI: 10.1093/eurheartj/ehac544.574
Abstract: BACKGROUND There are limited comparative data on safety and efficacy within commonly used Vaughan-Williams (VW) class III antiarrhythmic drugs (AADs) for maintenance of sinus rhythm in adults with atrial fibrillation (AF). HYPOTHESIS We hypothesized that dronedarone and… read more here.
Keywords: systematic literature; safety efficacy; analysis; sotalol ... See more keywords
P1034Impact of ablation status on the efficacy and safety of dronedarone in patients with atrial fibrillation/flutter: a post-hoc analysis of the ATHENA trial
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DOI: 10.1093/eurheartj/ehz747.0625
Abstract: Despite increasing use of ablation for atrial fibrillation/flutter (AF/AFL), few systematic data exist on the use of dronedarone and other antiarrhythmic drugs after ablation. To assess efficacy and safety of dronedarone after ablation in patients… read more here.
Keywords: ablation; dronedarone; safety; athena trial ... See more keywords
P1903Efficacy and safety of dronedarone after recent cardioversion in patients with atrial fibrillation/flutter: a post-hoc analysis of the EURIDIS/ADONIS trials
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DOI: 10.1093/eurheartj/ehz748.0650
Abstract: Cardioversion is commonly performed prior to antiarrhythmic drug initiation for atrial fibrillation/flutter (AF). There are limited data describing baseline differences in patients requiring cardioversion to maintain sinus rhythm compared to those who do not. Likewise,… read more here.
Keywords: hazard ratio; euridis adonis; dronedarone; versus ... See more keywords
Cardiovascular outcomes in patients with atrial fibrillation concomitantly treated with antiarrhythmic drugs and non-vitamin k antagonist oral anticoagulants
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DOI: 10.1093/europace/euad083
Abstract: Abstract Aims Limited data compared antiarrhythmic drugs (AADs) with concomitant non-vitamin K antagonist oral anticoagulants in atrial fibrillation patients, hence the aim of the study. Methods and results National health insurance database were retrieved during… read more here.
Keywords: vitamin antagonist; non vitamin; dronedarone; antagonist oral ... See more keywords
Rational deuteration of dronedarone attenuates its toxicity in human hepatic HepG2 cells.
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DOI: 10.1093/toxres/tfac017
Abstract: Deuteration is a chemical modification strategy that has recently gained traction in drug development. The replacement of one or more hydrogen atom(s) in a drug molecule with its heavier stable isotope deuterium can enhance its… read more here.
Keywords: deuteration; rational deuteration; deuteration dronedarone; dronedarone ... See more keywords
Comparative Safety and Effectiveness of Sotalol Versus Dronedarone After Catheter Ablation for Atrial Fibrillation.
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DOI: 10.1161/jaha.120.020506
Abstract: Background Atrial tachyarrhythmias are common after atrial fibrillation ablation, so adjunctive antiarrhythmic drug therapy is often used. Data on the effectiveness and safety of dronedarone and sotalol after AF ablation are limited. Here, we compared… read more here.
Keywords: versus; ahr months; atrial fibrillation; ablation ... See more keywords
Clove Oil Endorsed Transdermal Flux of Dronedarone Hydrochloride Loaded Bilosomal Nanogel: Factorial Design, In vitro Evaluation and Ex vivo Permeation
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DOI: 10.1208/s12249-022-02337-2
Abstract: The goal of this study was to develop a bilosomal gel formulation to enhance transdermal permeability of dronedarone hyrdrochloride (DRN) which suffers from poor oral absorption and limited bioavailability. To overcome this obstacle, bilosomes were… read more here.
Keywords: factorial design; vivo permeation; clove oil; design ... See more keywords
Dronedarone attenuates the duration of atrial fibrillation in a dog model of sustained atrial fibrillation
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DOI: 10.1538/expanim.17-0002
Abstract: Atrial fibrillation (AF) is a supraventricular arrhythmia that leads to a decrease in cardiac output and impairs cardiac function and quality of life. Dronedarone has an atrial-selective property and has been used for management of… read more here.
Keywords: atrial fibrillation; dog model; dronedarone; duration ... See more keywords
Functional Analysis of Wild-Type and 27 CYP3A4 Variants on Dronedarone Metabolism in Vitro.
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DOI: 10.2174/1389200223666220613153917
Abstract: Background：Cytochrome P450 (P450) is the largest family of enzymatic proteins in the human liver, and its features have been studied in physiology, medicine, biotechnol-ogy, and phytoremediation. OBJECTIVE The aim of this study was to assess… read more here.
Keywords: metabolism; dronedarone; cyp3a4; cyp3a4 alleles ... See more keywords
A value-based budget impact model for dronedarone compared with other rhythm control strategies.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of comparative effectiveness research"
DOI: 10.57264/cer-2022-0196
Abstract: Aim: The budgetary consequences of increasing dronedarone utilization for treatment of atrial fibrillation were evaluated from a US payer perspective. Materials & methods: A budget impact model over a 5-year time horizon was developed, including… read more here.
Keywords: dronedarone; impact model; control; budget impact ... See more keywords