Design and analysis of drop-the-losers studies using binary endpoints in the rare disease setting
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DOI: 10.1080/10543406.2021.1918139
Abstract: ABSTRACT The drop-the-losers design combines a phase 2 trial of k treatments and a confirmatory phase 3 trial under a single adaptive protocol, thereby gaining efficiency over a traditional clinical development approach. Such designs may… read more here.
Keywords: design analysis; drop losers; disease setting; rare disease ... See more keywords