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   Articles with "drosha" as a keyword



Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation

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recommendations! Published in 2019 at "International Journal of Cancer"

DOI: 10.1002/ijc.31952

Abstract: Wilms tumor (WT) is the most common kidney cancer in childhood. Mutations in the microprocessor genes DROSHA and DGCR8 have been identified as putative oncogenic drivers, indicating a critical role of aberrant miRNA processing in… read more here.

Keywords: drosha; kidney development; tumor formation; tumor ... See more keywords

Genome-wide Mapping of DROSHA Cleavage Sites on Primary MicroRNAs and Noncanonical Substrates.

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recommendations! Published in 2017 at "Molecular cell"

DOI: 10.1016/j.molcel.2017.03.013

Abstract: MicroRNA (miRNA) maturation is initiated by DROSHA, a double-stranded RNA (dsRNA)-specific RNase III enzyme. By cleaving primary miRNAs (pri-miRNAs) at specific positions, DROSHA serves as a main determinant of miRNA sequences and a highly selective… read more here.

Keywords: mirna; drosha cleavage; fclip; cleavage sites ... See more keywords

fCLIP-seq for transcriptomic footprinting of dsRNA-binding proteins: Lessons from DROSHA.

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recommendations! Published in 2019 at "Methods"

DOI: 10.1016/j.ymeth.2018.06.004

Abstract: CLIP-seq (crosslinking immunoprecipitation and sequencing) is widely used to map the binding sites of a protein of interest on the transcriptome, and generally employs UV to induce the covalent bonds between protein and RNA, which… read more here.

Keywords: seq; binding proteins; drosha; dsrna binding ... See more keywords

The Drosha rs10719 T>C polymorphism is associated with preeclampsia susceptibility

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recommendations! Published in 2018 at "Clinical and Experimental Hypertension"

DOI: 10.1080/10641963.2017.1392555

Abstract: ABSTRACT Purpose: Drosha is a member of the micro RNA (miRNA) processing machinery that affects miRNA processing. Single-nucleotide polymorphisms (SNPs) in the Drosha gene might affect microRNA processing and the expression of various genes. The… read more here.

Keywords: risk; susceptibility; drosha rs10719; drosha ... See more keywords

Novel, abundant Drosha isoforms are deficient in miRNA processing in cancer cells

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recommendations! Published in 2020 at "RNA Biology"

DOI: 10.1080/15476286.2020.1813439

Abstract: ABSTRACT MicroRNAs (miRNAs) are a class of small noncoding RNAs about 22-nucleotide (nt) in length that collectively regulate more than 60% of coding genes. Aberrant miRNA expression is associated with numerous diseases, including cancer. miRNA… read more here.

Keywords: abundant drosha; mirna; novel abundant; drosha isoforms ... See more keywords

Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition

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recommendations! Published in 2025 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-24-2785

Abstract: Abstract Purpose: DROSHA, DGCR8, and DICER1 regulate miRNA biogenesis and are commonly mutated in cancer. Although DGCR8 and DICER1 germline pathogenic variants (GPV) cause autosomal dominant tumor predisposition, no association between DROSHA GPVs and clinical… read more here.

Keywords: tumor predisposition; wilms tumor; drosha; drosha gpvs ... See more keywords

Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0182445

Abstract: Canonical processing of miRNA begins in the nucleus with the Microprocessor complex, which is minimally composed of the RNase III enzyme Drosha and two copies of its cofactor protein DGCR8. In structural analogy to most… read more here.

Keywords: dsrbd; rna binding; double stranded; stranded rna ... See more keywords

Immunohistochemical expression of Drosha is reduced in eutopic and ectopic endometrium of women with adenomyosis

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recommendations! Published in 2022 at "Brazilian Journal of Medical and Biological Research"

DOI: 10.1590/1414-431x2022e12375

Abstract: The objective of this study was to evaluate the immunohistochemical expression of Dicer, Drosha, and Exportin-5 in the eutopic and ectopic endometrium of women with adenomyosis. Twenty-two paired ectopic and eutopic endometrium from women with… read more here.

Keywords: endometrium; eutopic endometrium; expression; women adenomyosis ... See more keywords

Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer

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recommendations! Published in 2021 at "Frontiers in Molecular Biosciences"

DOI: 10.3389/fmolb.2021.730006

Abstract: In complex biochemical systems, an enzyme, protein, or RNA, symbolized as E, has hundreds or thousands of substrates or interacting partners. The relative specificity hypothesis proposes that such an E would differentially interact with and… read more here.

Keywords: mirna; drosha; relative specificity; drosha dicer ... See more keywords

Association of DROSHA Variants with Susceptibility and Outcomes in Childhood Acute Lymphoblastic Leukemia

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recommendations! Published in 2025 at "Current Issues in Molecular Biology"

DOI: 10.3390/cimb47060473

Abstract: MicroRNAs are key regulators of lymphoid differentiation, exhibiting a pivotal role in acute lymphoblastic leukemia (ALL) biology and prognosis. The initial steps of canonical miRNA biogenesis involve the microprocessor complex processing the primary miRNA transcripts… read more here.

Keywords: susceptibility; drosha; lymphoblastic leukemia; acute lymphoblastic ... See more keywords

Relationship Between the Occurrence of Depression and DROSHA (rs6877842, rs10719) and XPO5 (rs11077) Single-Nucleotide Polymorphisms in the Polish Population: A Case–Control Study

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recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms252212204

Abstract: Although the epidemiology and symptoms of major depressive disorder (MDD) have been well-documented, the etiology and pathophysiology of the disease have not yet been fully explained. Depression arises from intricate interplay among social, psychological, and… read more here.

Keywords: drosha; single nucleotide; depression; xpo5 ... See more keywords