Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31952
Abstract: Wilms tumor (WT) is the most common kidney cancer in childhood. Mutations in the microprocessor genes DROSHA and DGCR8 have been identified as putative oncogenic drivers, indicating a critical role of aberrant miRNA processing in… read more here.
Keywords: drosha; kidney development; tumor formation; tumor ... See more keywords
Genome-wide Mapping of DROSHA Cleavage Sites on Primary MicroRNAs and Noncanonical Substrates.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.03.013
Abstract: MicroRNA (miRNA) maturation is initiated by DROSHA, a double-stranded RNA (dsRNA)-specific RNase III enzyme. By cleaving primary miRNAs (pri-miRNAs) at specific positions, DROSHA serves as a main determinant of miRNA sequences and a highly selective… read more here.
Keywords: mirna; drosha cleavage; fclip; cleavage sites ... See more keywords
fCLIP-seq for transcriptomic footprinting of dsRNA-binding proteins: Lessons from DROSHA.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2018.06.004
Abstract: CLIP-seq (crosslinking immunoprecipitation and sequencing) is widely used to map the binding sites of a protein of interest on the transcriptome, and generally employs UV to induce the covalent bonds between protein and RNA, which… read more here.
Keywords: seq; binding proteins; drosha; dsrna binding ... See more keywords
The Drosha rs10719 T>C polymorphism is associated with preeclampsia susceptibility
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2017.1392555
Abstract: ABSTRACT Purpose: Drosha is a member of the micro RNA (miRNA) processing machinery that affects miRNA processing. Single-nucleotide polymorphisms (SNPs) in the Drosha gene might affect microRNA processing and the expression of various genes. The… read more here.
Keywords: risk; susceptibility; drosha rs10719; drosha ... See more keywords
Novel, abundant Drosha isoforms are deficient in miRNA processing in cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "RNA Biology"
DOI: 10.1080/15476286.2020.1813439
Abstract: ABSTRACT MicroRNAs (miRNAs) are a class of small noncoding RNAs about 22-nucleotide (nt) in length that collectively regulate more than 60% of coding genes. Aberrant miRNA expression is associated with numerous diseases, including cancer. miRNA… read more here.
Keywords: abundant drosha; mirna; novel abundant; drosha isoforms ... See more keywords
Engineering double-stranded RNA binding activity into the Drosha double-stranded RNA binding domain results in a loss of microRNA processing function
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0182445
Abstract: Canonical processing of miRNA begins in the nucleus with the Microprocessor complex, which is minimally composed of the RNase III enzyme Drosha and two copies of its cofactor protein DGCR8. In structural analogy to most… read more here.
Keywords: dsrbd; rna binding; double stranded; stranded rna ... See more keywords
Immunohistochemical expression of Drosha is reduced in eutopic and ectopic endometrium of women with adenomyosis
Sign Up to like & getrecommendations! Published in 2022 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x2022e12375
Abstract: The objective of this study was to evaluate the immunohistochemical expression of Dicer, Drosha, and Exportin-5 in the eutopic and ectopic endometrium of women with adenomyosis. Twenty-two paired ectopic and eutopic endometrium from women with… read more here.
Keywords: endometrium; eutopic endometrium; expression; women adenomyosis ... See more keywords
Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.730006
Abstract: In complex biochemical systems, an enzyme, protein, or RNA, symbolized as E, has hundreds or thousands of substrates or interacting partners. The relative specificity hypothesis proposes that such an E would differentially interact with and… read more here.
Keywords: mirna; drosha; relative specificity; drosha dicer ... See more keywords