Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition
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DOI: 10.1158/1078-0432.ccr-24-2785
Abstract: Abstract Purpose: DROSHA, DGCR8, and DICER1 regulate miRNA biogenesis and are commonly mutated in cancer. Although DGCR8 and DICER1 germline pathogenic variants (GPV) cause autosomal dominant tumor predisposition, no association between DROSHA GPVs and clinical… read more here.
Keywords: tumor predisposition; wilms tumor; drosha; drosha gpvs ... See more keywords