P53 and Apoptosis in the Drosophila Model.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-23629-8_6
Abstract: Human P53 (HsP53) is the most frequently mutated gene associated with cancers. Despite heightened research interest over the last four decades, a clear picture of how wild type HsP53 functions as the guardian against malignant… read more here.
Keywords: apoptosis drosophila; drosophila model; model; p53 apoptosis ... See more keywords
A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.12.010
Abstract: &NA; Ubiquilin (UBQLN) plays a crucial role in cellular proteostasis through its involvement in the ubiquitin proteasome system and autophagy. Mutations in the UBQLN2 gene have been implicated in amyotrophic lateral sclerosis (ALS) and ALS… read more here.
Keywords: drosophila model; proteostasis; impaired proteostasis; new drosophila ... See more keywords
Defined d-hexapeptides bind CUG repeats and rescue phenotypes of myotonic dystrophy myotubes in a Drosophila model of the disease
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98866-0
Abstract: In Myotonic Dystrophy type 1 (DM1), a non-coding CTG repeats rare expansion disease; toxic double-stranded RNA hairpins sequester the RNA-binding proteins Muscleblind-like 1 and 2 (MBNL1 and 2) and trigger other DM1-related pathogenesis pathway defects.… read more here.
Keywords: drosophila model; bind cug; disease; myotonic dystrophy ... See more keywords
Splicing factors act as genetic modulators of TDP-43 production in a new autoregulatory TDP-43 Drosophila model
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx229
Abstract: TDP-43 is a critical RNA-binding factor associated with RNA metabolism. In the physiological state, maintaining normal TDP-43 protein levels is critical for proper physiological functions of the cells. As such, TDP-43 expression is tightly regulated… read more here.
Keywords: tdp production; drosophila model; production; genetic modulators ... See more keywords
Anthocyanins Function as Anti-Inflammatory Agents in a Drosophila Model for Adipose Tissue Macrophage Infiltration
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/6413172
Abstract: Epidemiological and preclinical studies have demonstrated that bioactive foods like flavonoids, polyphenolic compounds derived from fruits and vegetables, exert a protective action against obesity, cardiovascular disorders, and Adipocyte Tissue Macrophage infiltration (ATM). All these pathologies… read more here.
Keywords: drosophila model; tissue macrophage; macrophage infiltration; tissue ... See more keywords
Evaluating the Potential of Portulaca oleracea L. for Parkinson's Disease Treatment Using a Drosophila Model with dUCH-Knockdown
Sign Up to like & getrecommendations! Published in 2019 at "Parkinson's Disease"
DOI: 10.1155/2019/1818259
Abstract: Parkinson's disease (PD), which is characterized by the decreased motor function and the loss of dopaminergic neurons, is a common neurodegenerative disorder in elders. There have been numerous in vitro and in vivo models developed… read more here.
Keywords: drosophila model; treatment; disease; duch knockdown ... See more keywords
Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.158457
Abstract: Polyamine dysregulation plays key roles in a broad range of human diseases from cancer to neurodegeneration. Snyder-Robinson syndrome (SRS) is the first known genetic disorder of the polyamine pathway, caused by X-linked recessive loss-of-function mutations… read more here.
Keywords: snyder robinson; drosophila model; robinson syndrome; srs ... See more keywords
Drosophila as a Model for Microbiota Studies of Neurodegeneration
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-215031
Abstract: Accumulating evidence show that the gut microbiota is deeply involved not only in host nutrient metabolism but also in immune function, endocrine regulation, and chronic disease. In neurodegenerative conditions such as Alzheimer’s disease (AD), Parkinson’s… read more here.
Keywords: drosophila model; model microbiota; microbiota; disease ... See more keywords
Sexual dysfunction precedes motor defects, dopaminergic neuronal degeneration, and impaired dopamine metabolism: Insights from Drosophila model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1143793
Abstract: Sexual dysfunction (SD) is one of the most common non-motor symptoms of Parkinson’s disease (PD) and remains the most neglected, under-reported, and under-recognized aspect of PD. Studies have shown that Dopamine (DA) in the hypothalamus… read more here.
Keywords: drosophila model; behavior; parkinson disease; sexual dysfunction ... See more keywords
Efficient strategies based on behavioral and electrophysiological methods for epilepsy-related gene screening in the Drosophila model
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1121877
Abstract: Introduction With the advent of trio-based whole-exome sequencing, the identification of epilepsy candidate genes has become easier, resulting in a large number of potential genes that need to be validated in a whole-organism context. However,… read more here.
Keywords: efficient; candidate genes; drosophila model; model ... See more keywords
Drosophila as a Model to Study the Mechanism of Nociception
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.854124
Abstract: Nociception refers to the process of encoding and processing noxious stimuli, which allow animals to detect and avoid potentially harmful stimuli. Several types of stimuli can trigger nociceptive sensory transduction, including thermal, noxious chemicals, and… read more here.
Keywords: drosophila model; model study; nociception drosophila; nociception ... See more keywords