Using Drosophila Models and Tools to Understand the Mechanisms of Novel Human Cancer Driver Gene Function.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-23629-8_2
Abstract: The formation, overgrowth and metastasis of tumors comprise a complex series of cellular and molecular events resulting from the combined effects of a variety of aberrant signaling pathways, mutations, and epigenetic alterations. Modeling this complexity… read more here.
Keywords: drosophila models; models tools; using drosophila; cancer driver ... See more keywords
Drosophila Models to Investigate Insulin Action and Mechanisms Underlying Human Diabetes Mellitus.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-0529-0_13
Abstract: Diabetes is a group of metabolic diseases in which the patient shows elevated levels of blood sugar. In healthy condition, there is the regulatory system that maintains constant glucose levels in blood. It is accomplished… read more here.
Keywords: investigate insulin; drosophila models; blood; models investigate ... See more keywords
Drosophila models of FOP provide mechanistic insight.
Sign Up to like & getrecommendations! Published in 2018 at "Bone"
DOI: 10.1016/j.bone.2017.11.001
Abstract: Fibrodysplasia ossificans progressiva (FOP) is a rare bone disease characterized by episodic events of heterotopic ossification (HO). All cases of FOP have been attributed to mutations in the ACVR1 gene that render the encoded BMP… read more here.
Keywords: drosophila; bmp signaling; drosophila models; models fop ... See more keywords
Abnormal visual gain control and excitotoxicity in early-onset Parkinson’s disease Drosophila models
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurophysiology"
DOI: 10.1152/jn.00681.2017
Abstract: The excitotoxic theory of Parkinson’s disease (PD) hypothesizes that a pathophysiological degeneration of dopaminergic neurons stems from neural hyperactivity at early stages of disease, leading to mitochondrial stress and cell death. Recent research has harnessed… read more here.
Keywords: drosophila; excitotoxicity; drosophila models; gain control ... See more keywords
Effects of mutant lamins on nucleo-cytoskeletal coupling in Drosophila models of LMNA muscular dystrophy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.934586
Abstract: The nuclei of multinucleated skeletal muscles experience substantial external force during development and muscle contraction. Protection from such forces is partly provided by lamins, intermediate filaments that form a scaffold lining the inner nuclear membrane.… read more here.
Keywords: mutant lamins; drosophila models; muscular dystrophy; cytoskeletal coupling ... See more keywords
Deciphering mechanisms of action of ACE inhibitors in neurodegeneration using Drosophila models of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1166973
Abstract: Alzheimer’s disease (AD) is a devastating neurodegenerative disorder for which there is no cure. Recently, several studies have reported a significant reduction in the incidence and progression of dementia among some patients receiving antihypertensive medications… read more here.
Keywords: deciphering mechanisms; alzheimer disease; ace arbs; drosophila models ... See more keywords
DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer’s Disease-Down Syndrome Phenotypes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.881385
Abstract: Alzheimer’s disease (AD) is the most common neurodegenerative disease which is becoming increasingly prevalent due to ageing populations resulting in huge social, economic, and health costs to the community. Despite the pathological processing of genes… read more here.
Keywords: tau; dyrk1a inhibitor; alzheimer disease; dyrk1a ... See more keywords
TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12020101
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal, complex neurodegenerative disorder that causes selective degeneration of motor neurons. ALS patients exhibit symptoms consistent with altered cellular energetics such as hypermetabolism, weight loss, dyslipidemia, insulin resistance, and… read more here.
Keywords: drosophila models; cycle; tca cycle; dopamine levels ... See more keywords