Biotransformation of drospirenone, a contraceptive drug, with Cunninghamella elegans
Sign Up to like & getrecommendations! Published in 2017 at "Steroids"
DOI: 10.1016/j.steroids.2017.07.010
Abstract: &NA; Biotransformation of an orally active contraceptive drug, drospirenone (1), by Cunninghamella elegans ATCC 36114 yielded four new metabolites, 6&bgr;,7&bgr;,15&bgr;,16&bgr;‐dimethylene‐3‐oxo‐14&agr;‐hydroxy‐17&agr;‐pregn‐4‐ene‐21,17‐carbolactone (2), 6&bgr;,7&bgr;,15&bgr;,16&bgr;‐dimethylene‐3,11‐dioxo‐17&agr;‐pregn‐4‐ene‐21,17‐carbolactone (3), 6&bgr;,7&bgr;,15&bgr;,16&bgr;‐dimethylene‐3,12‐dioxo‐17&agr;‐pregn‐4‐ene‐21,17‐carbolactone (4), and 6&bgr;,7&bgr;,15&bgr;,16&bgr;‐dimethylene‐3‐oxo‐11&bgr;,14&agr;‐dihydroxy‐17&agr;‐pregn‐4‐ene‐21,17‐carbolactone (5), along with a known metabolite, 6&bgr;,7&bgr;,15&bgr;,16&bgr;‐dimethylene‐3‐oxo‐11&agr;‐dihydroxy‐17&agr;‐pregn‐4‐ene‐21,17‐carbolactone (6).… read more here.
Keywords: contraceptive drug; bgr; agr; bgr bgr ... See more keywords
Inconsistencies in laboratory investigations of hypertension in a young woman taking ethinylestradiol/drospirenone association.
Sign Up to like & getrecommendations! Published in 2022 at "Acta clinica Belgica"
DOI: 10.1080/17843286.2022.2132764
Abstract: CASE PRESENTATION A 34-year-old woman presented to the emergency department for arterial hypertension. Blood analysis requested by the endocrinologist showed very high level of aldosterone (1805 ng/L, normal values: read more here.
Keywords: drospirenone; renin; ethinylestradiol drospirenone; drospirenone association ... See more keywords
Multicenter, phase III trials on the contraceptive efficacy, tolerability and safety of a new drospirenone‐only pill
Sign Up to like & getrecommendations! Published in 2019 at "Acta Obstetricia et Gynecologica Scandinavica"
DOI: 10.1111/aogs.13688
Abstract: Approximately 100 million women currently use combined oral contraceptives. Combined oral contraceptives use is associated with increased risk of venous thromboembolic events and cardiovascular disease. Progestin‐only pills do not increase the risk of venous thromboembolic… read more here.
Keywords: thromboembolic events; tolerability; drospirenone; pill ... See more keywords
Pharmacological and metabolic effects of drospirenone as a progestin-only pill compared to combined formulations with estrogen
Sign Up to like & getrecommendations! Published in 2023 at "Women's Health"
DOI: 10.1177/17455057221147388
Abstract: The spironolactone derivative drospirenone is combined with ethinylestradiol or estetrol in combined oral contraceptives. Formulations with 17-β-estradiol are used to treat climacteric symptoms. A drospirenone-only formulation has been introduced for contraception. Here, the pharmacological properties… read more here.
Keywords: drospirenone; pharmacological metabolic; effects drospirenone; progestin pill ... See more keywords
Estetrol and drospirenone: a novel oral contraceptive.
Sign Up to like & getrecommendations! Published in 2022 at "Drugs of today"
DOI: 10.1358/dot.2022.58.1.3353167
Abstract: Estetrol (E₄) is a natural human estrogen produced during human pregnancy in the fetal liver with a unique mechanism of action that displays tissue-selective activity, and behaves as a natural selective estrogen receptor modulator. E₄… read more here.
Keywords: novel oral; drospirenone novel; drospirenone; oral contraceptive ... See more keywords
Drospirenone-containing oral contraceptives do not affect glucose regulation and circulating corticosterone
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Basic and Clinical Physiology and Pharmacology"
DOI: 10.1515/jbcpp-2018-0184
Abstract: Abstract Background Combined oral contraceptive (COC) use has been associated with an increased risk of insulin resistance (IR) and other adverse cardiovascular events, despite efforts to reduce the dosage and/or progestin type. COC containing drospirenone… read more here.
Keywords: coc; corticosterone; affect glucose; drospirenone ... See more keywords
Drospirenone and mood
Sign Up to like & getrecommendations! Published in 2022 at "Australian Prescriber"
DOI: 10.18773/austprescr.2022.048
Abstract: The 4 mg drospirenone preparation became available in Australia in October 2021 after we wrote the article.1 For contraceptives containing drospirenone, a 2012 Cochrane meta-analysis tentatively described improvement in women with premenstrual dysphoric disorder, however… read more here.
Keywords: premenstrual dysphoric; drospirenone; drospirenone mood; dysphoric disorder ... See more keywords
Confirmation of the Drug–drug Interaction Potential between Cobicistat-boosted Antiretroviral Regimens and Hormonal Contraceptives
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral Therapy"
DOI: 10.3851/imp3343
Abstract: Background Cobicistat (COBI), a CYP3A inhibitor, is a pharmacokinetic enhancer that increases exposures of the HIV protease inhibitors (PIs) atazanavir (ATV) and darunavir (DRV). The potential drug interaction between COBI-boosted PIs and hormonal contraceptives, which… read more here.
Keywords: cobi; drug interaction; drospirenone; atv cobi ... See more keywords