Drotaverine Inhibitor of PDE4: Reverses the Streptozotocin Induced Alzheimer's Disease in Mice.
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DOI: 10.1007/s11064-021-03327-9
Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with decline in memory and cognitive impairments. Phosphodiesterase IV (PDE4) protein, an intracellular cAMP levels regulator, when inhibited act as potent neuroprotective agents by virtue of… read more here.
Keywords: inhibitor; alzheimer disease; drotaverine; group ... See more keywords
Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine
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DOI: 10.1159/000485921
Abstract: Background: Drotaverine, a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor, blocks the degradation of 3’,5’-cyclic adenosine monophosphate. However, published receptor binding data showed that drotaverin also binds to the L-type voltage-operated calcium channel (L-VOCC). Based… read more here.
Keywords: muscle relaxant; drotaverine; smooth muscle; relaxant effect ... See more keywords