DRP1 contributes to head and neck cancer progression and induces glycolysis through modulated FOXM1/MMP12 axis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13212
Abstract: Abnormal DRP1 expression has been identified in a variety of human cancers. However, the prognostic potential and mechanistic role of DRP1 in head and neck cancer (HNC) are currently poorly understood. Here, we demonstrated a… read more here.
Keywords: drp1; drp1 expression; expression; foxm1 mmp12 ... See more keywords
The strange case of Drp1 in autophagy: Jekyll and Hyde?
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202100271
Abstract: There is a debate regarding the function of Drp1, a GTPase involved in mitochondrial fission, during the elimination of mitochondria by autophagy. A number of experiments indicate that Drp1 is needed to eliminate mitochondria during… read more here.
Keywords: drp1; autophagy jekyll; drp1 autophagy; strange case ... See more keywords
The role of Cdk5‐mediated Drp1 phosphorylation in Aβ1‐42 induced mitochondrial fission and neuronal apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26680
Abstract: Alzheimer's disease, one of the most common neurodegenerative diseases, is pathologically characterized by Amyloid beta containing plaques and neurofibrillary tangles. Amyloid beta (Aβ) induces neuronal apoptosis through the intracellular Ca2+ increase, subsequent hyperactivation of cyclin‐dependent… read more here.
Keywords: fission; neuronal apoptosis; mitochondrial fission; cdk5 ... See more keywords
Hippo/Mst1 overexpression induces mitochondrial death in head and neck squamous cell carcinoma via activating β-catenin/Drp1 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-019-01008-9
Abstract: Mammalian Ste20-like kinase 1 (Mst1) is associated with cell apoptosis. In the current study, we explored the regulatory effects of Mst1 on squamous cell carcinoma of the head and neck (SCCHN) in vitro. SCCHN Cal27… read more here.
Keywords: drp1; mst1 overexpression; cell; catenin ... See more keywords
Acrolein Aggravates Secondary Brain Injury After Intracerebral Hemorrhage Through Drp1-Mediated Mitochondrial Oxidative Damage in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-020-00505-7
Abstract: Clinical advances in the treatment of intracranial hemorrhage (ICH) are restricted by the incomplete understanding of the molecular mechanisms contributing to secondary brain injury. Acrolein is a highly active unsaturated aldehyde which has been implicated… read more here.
Keywords: secondary brain; brain; damage; brain injury ... See more keywords
Mitochondrial dynamics and protective effects of a mitochondrial division inhibitor, Mdivi-1, in lipopolysaccharide-induced brain damage.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.136
Abstract: Sepsis is one of the most common reasons for mortality in Intensive Care Units. As a common but severe neurological complication, sepsis associated encephalopathy (SAE) has always been ignored and there is no generally accepted… read more here.
Keywords: mitochondrial dynamics; brain damage; drp1; inhibitor ... See more keywords
CaMK II -induced Drp1 phosphorylation contributes to blue light-induced AIF-mediated necroptosis in retinal R28 cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.04.082
Abstract: Retinal damage caused by blue light has become an important public health concern. Mitochondria have been found to play a key role in light-induced retinal cell death. In this study, we aimed to clarify the… read more here.
Keywords: blue light; cell; light induced; light ... See more keywords
Drp1-mediated mitochondrial fission contributes to mitophagy in paraquat-induced neuronal cell damage.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.116413
Abstract: Paraquat (PQ) is one of the most widely used herbicides in the world due to its excellent weed control effects. Accumulating evidence has revealed that long-term exposure to PQ can significantly increase the risk of… read more here.
Keywords: paraquat; mediated mitochondrial; excessive mitophagy; mitochondrial fission ... See more keywords
Drp1 regulates mitochondrial morphology and cell proliferation in cutaneous squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2017.08.004
Abstract: BACKGROUND Dynamin-related protein 1 (Drp1) mediates mitochondrial fission. Recently, several studies have shown that Drp1 plays an important role in some cancers. However, little is known about Drp1 in cutaneous squamous cell carcinoma (SCC). OBJECTIVE… read more here.
Keywords: cell proliferation; drp1; cell; mitochondrial morphology ... See more keywords
Ophiopogonin D Alleviates Diabetic Myocardial Injuries by Regulating Mitochondrial Dynamics.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.113853
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Ophiopogonin D (OP-D) is a steroidal saponin extracted from Ophiopogon japonicus (Thunb.) Ker Gawl. (Liliaceae), that has been traditionally used to treat cough, sputum, and thirst in some Asian countries. Recently, various pharmacological… read more here.
Keywords: palmitic acid; drp1; diabetic myocardial; mitochondrial dynamics ... See more keywords
ERK1/2-Mediated Activation of DRP1 Regulates Mitochondrial Dynamics and Apoptosis in Chondrocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2021.11.003
Abstract: OBJECTIVE To determine the Dynamin-related protein 1 (DRP1) regulation of mitochondrial fission in chondrocytes under pathological conditions, an area which is underexplored in osteoarthritis pathogenesis. DESIGN DRP1 protein expression was determined by IHC or IF… read more here.
Keywords: apoptosis chondrocytes; erk1 mediated; apoptosis; expression ... See more keywords