DRP1 contributes to head and neck cancer progression and induces glycolysis through modulated FOXM1/MMP12 axis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13212
Abstract: Abnormal DRP1 expression has been identified in a variety of human cancers. However, the prognostic potential and mechanistic role of DRP1 in head and neck cancer (HNC) are currently poorly understood. Here, we demonstrated a… read more here.
Keywords: drp1; drp1 expression; expression; foxm1 mmp12 ... See more keywords
The strange case of Drp1 in autophagy: Jekyll and Hyde?
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202100271
Abstract: There is a debate regarding the function of Drp1, a GTPase involved in mitochondrial fission, during the elimination of mitochondria by autophagy. A number of experiments indicate that Drp1 is needed to eliminate mitochondria during… read more here.
Keywords: drp1; autophagy jekyll; drp1 autophagy; strange case ... See more keywords
Conformational Rearrangement of Fission DSPs
Sign Up to like & getrecommendations! Published in 2025 at "Bioessays"
DOI: 10.1002/bies.70062
Abstract: Dynamin superfamily proteins (DSPs) are large GTPases that play crucial roles in membrane remodeling processes, including vesicle uptake, mitochondrial fission, and opposing fusion events. Among them, dynamin and dynamin‐related protein 1 (Drp1) share a conserved… read more here.
Keywords: rearrangement fission; fission; dynamin; fission dsps ... See more keywords
Analysis of the serum levels of RIP3 and Drp1 in patients with heart failure
Sign Up to like & getrecommendations! Published in 2024 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14771
Abstract: As necroptosis involving receptor‐interacting protein kinase 3 (RIP3) and dynamin‐related protein 1 (Drp1)‐mediated signalling is a crucial mechanism of cell loss in heart failure (HF), we aimed to determine the potential diagnostic use of these… read more here.
Keywords: heart; analysis serum; failure analysis; heart failure ... See more keywords
The role of Cdk5‐mediated Drp1 phosphorylation in Aβ1‐42 induced mitochondrial fission and neuronal apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26680
Abstract: Alzheimer's disease, one of the most common neurodegenerative diseases, is pathologically characterized by Amyloid beta containing plaques and neurofibrillary tangles. Amyloid beta (Aβ) induces neuronal apoptosis through the intracellular Ca2+ increase, subsequent hyperactivation of cyclin‐dependent… read more here.
Keywords: fission; neuronal apoptosis; mitochondrial fission; cdk5 ... See more keywords
Reniformin A Suppresses Triple‐Negative Breast Cancer Progression by Inducing DRP1‐Mediated Mitochondrial Dysfunction and Apoptosis
Sign Up to like & getrecommendations! Published in 2025 at "Phytotherapy Research"
DOI: 10.1002/ptr.70034
Abstract: Reniformin A (RA) is a natural compound extracted from the medicinal herb Isodon excisoides, known for its tumor‐suppressive properties in lung cancer. Yet, its effects and mechanisms of action in other cancers, such as triple‐negative… read more here.
Keywords: breast cancer; negative breast; triple negative; apoptosis ... See more keywords
ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1‐Mediated Mitochondrial Dynamic
Sign Up to like & getrecommendations! Published in 2024 at "Synapse"
DOI: 10.1002/syn.22309
Abstract: After seizures, the hyperactivation of extracellular signal‐regulated kinases (ERK1/2) causes mitochondrial dysfunction. Through the guidance of dynamin‐related protein 1 (DRP1), ERK1/2 plays a role in the pathogenesis of several illnesses. Herein, we speculate that ERK1/2… read more here.
Keywords: erk1; erk1 drp1; drp1 mediated; drp1 ser616 ... See more keywords
Hippo/Mst1 overexpression induces mitochondrial death in head and neck squamous cell carcinoma via activating β-catenin/Drp1 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-019-01008-9
Abstract: Mammalian Ste20-like kinase 1 (Mst1) is associated with cell apoptosis. In the current study, we explored the regulatory effects of Mst1 on squamous cell carcinoma of the head and neck (SCCHN) in vitro. SCCHN Cal27… read more here.
Keywords: drp1; mst1 overexpression; cell; catenin ... See more keywords
Acrolein Aggravates Secondary Brain Injury After Intracerebral Hemorrhage Through Drp1-Mediated Mitochondrial Oxidative Damage in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-020-00505-7
Abstract: Clinical advances in the treatment of intracranial hemorrhage (ICH) are restricted by the incomplete understanding of the molecular mechanisms contributing to secondary brain injury. Acrolein is a highly active unsaturated aldehyde which has been implicated… read more here.
Keywords: secondary brain; brain; damage; brain injury ... See more keywords
Mitochondrial dynamics and protective effects of a mitochondrial division inhibitor, Mdivi-1, in lipopolysaccharide-induced brain damage.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.136
Abstract: Sepsis is one of the most common reasons for mortality in Intensive Care Units. As a common but severe neurological complication, sepsis associated encephalopathy (SAE) has always been ignored and there is no generally accepted… read more here.
Keywords: mitochondrial dynamics; brain damage; drp1; inhibitor ... See more keywords
CaMK II -induced Drp1 phosphorylation contributes to blue light-induced AIF-mediated necroptosis in retinal R28 cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.04.082
Abstract: Retinal damage caused by blue light has become an important public health concern. Mitochondria have been found to play a key role in light-induced retinal cell death. In this study, we aimed to clarify the… read more here.
Keywords: blue light; cell; light induced; light ... See more keywords