Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.12.004
Abstract: Huntington's disease (HD) is a fatal hereditary neurodegenerative disorder, best known for its clinical triad of progressive motor impairment, cognitive deficits and psychiatric disturbances, is caused by CAG-repeat expansion in exon 1 of Huntingtin (HTT).… read more here.
Keywords: dysfunction; disease; fis1 mediated; drp1 fis1 ... See more keywords
Inhibition of DRP1–FIS1–Mediated mitochondrial fission as a novel strategy to prevent gvhd
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-2310
Abstract: Graft-versus-host disease (GVHD) remains a leading cause of non-relapse mortality following hematopoietic stem cell transplantation (HSCT). GVHD is primarily driven by the activation of donor T cells by host-derived antigen-presenting cells (APCs), a process that… read more here.
Keywords: mitochondrial fission; drp1 fis1; gvhd; strategy ... See more keywords