A compartment-quasi-3D multiscale approach for drug absorption, transport, and retention in the human lungs.
Sign Up to like & getrecommendations! Published in 2018 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.2955
Abstract: Most current models used for modeling the pulmonary drug absorption, transport, and retention are 0D compartmental models where the airways are generally split into the airways and alveolar sections. Such block models deliver low fidelity… read more here.
Keywords: drug absorption; transport; drug; model ... See more keywords
Intestinal Transporter-Associated Drug Absorption and Toxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-7647-4_8
Abstract: Oral drug administration is the most favorable route of drug administration in the clinic. Intestinal transporters have been shown to play a significant role in the rate and extent of drug absorption of some, but… read more here.
Keywords: absorption; transporter associated; drug absorption; drug ... See more keywords
Nasal drug absorption from powder formulations: The effect of three types of hydroxypropyl cellulose (HPC)
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DOI: 10.1016/j.ejps.2016.09.028
Abstract: &NA; Despite the numerous advantages of powder formulations, few studies have described their nasal drug absorption. The first aim of this study was to compare the drug absorption from powder formulation with that from a… read more here.
Keywords: absorption; drug absorption; drug; hpc ... See more keywords
The Effects of Bariatric Surgery on Pharmacokinetics of Antidepressants: A Systematic Review
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DOI: 10.1016/j.eurpsy.2017.01.2244
Abstract: Introduction Morbid obesity (BMI ≥ 35) has been associated with mood and anxiety disorders. Regular use of antidepressants is common among patients who are candidate for bariatric surgery. The Roux-en-Y gastric bypass (RYGB) is one… read more here.
Keywords: dissolution; surgery; bariatric surgery; drug absorption ... See more keywords
In Vitro Characterization of the Biomimetic Properties of Poly(dimethylsiloxane) To Simulate Oral Drug Absorption.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00798
Abstract: The potential use of poly(dimethylsiloxane) (PDMS) as an in vitro biomimetic analogue of the passive drug absorption process in the human gastrointestinal tract (GI) is assessed. PDMS is biomimetic because of similarities in small molecule… read more here.
Keywords: absorption; drug absorption; drug; partition ... See more keywords
Ethanol Interactions With Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Psychopharmacology"
DOI: 10.1097/jcp.0000000000000721
Abstract: Background/Purpose Ethanol coadministered with immediate-release dl-methylphenidate (dl-MPH) or dexmethylphenidate (d-MPH) significantly increases the geomean maximum plasma concentration (Cmax) of d-MPH 22% and 15%, respectively, and elevates overall drug exposure and psychostimulant effects. We asked the… read more here.
Keywords: oral drug; mph; drug absorption; spheroidal oral ... See more keywords
A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption
Sign Up to like & getrecommendations! Published in 2018 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-018-0194-5
Abstract: BackgroundOral administration of drugs is convenient and shows good compliance but it can be affected by many factors in the gastrointestinal (GI) system. Consumption of food is one of the major factors affecting the GI… read more here.
Keywords: absorption; drug absorption; model; consumption ... See more keywords
In silico drug absorption tract: An agent-based biomimetic model for human oral drug absorption
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DOI: 10.1371/journal.pone.0203361
Abstract: Background An agent-based modeling approach has been suggested as an alternative to traditional, equation-based modeling methods for describing oral drug absorption. It enables researchers to gain a better understanding of the pharmacokinetic (PK) mechanisms of… read more here.
Keywords: absorption; drug absorption; oral drug; drug ... See more keywords
Utilization of Sodium Nitroprusside as an Intestinal Permeation Enhancer for Lipophilic Drug Absorption Improvement in the Rat Proximal Intestine
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DOI: 10.3390/molecules26216396
Abstract: As advanced synthetic technology has enabled drug candidate development with complex structure, resulting in low solubility and membrane permeability, the strategies to improve poorly absorbed drug bioavailability have attracted the attention of pharmaceutical companies. It… read more here.
Keywords: absorption; lipophilic drug; drug absorption; permeation ... See more keywords
Food Effects on Oral Drug Absorption: Application of Physiologically-Based Pharmacokinetic Modeling as a Predictive Tool
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DOI: 10.3390/pharmaceutics12070672
Abstract: The bioavailability of an orally administered small molecule is often dictated by drug-specific physicochemical characteristics and is influenced by many biological processes. For example, in fed or fasted conditions, the transit time within the gastrointestinal… read more here.
Keywords: physiologically based; food effects; food; drug absorption ... See more keywords
Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation
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DOI: 10.3390/pharmaceutics13020272
Abstract: The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these… read more here.
Keywords: absorption; drug absorption; regional intestinal; absorption biopharmaceutics ... See more keywords