Mechano-Nanoswitches for Ultrasound-Controlled Drug Activation.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202104696
Abstract: Current pharmacotherapy is challenged by side effects and drug resistance issues due to the lack of drug selectivity. Mechanochemistry-based strategies provide new avenues to overcome the related problems by improving drug selectivity. It is recently… read more here.
Keywords: controlled drug; activation; drug; drug activation ... See more keywords
Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c01622
Abstract: The ability to create ways to control drug activation at specific tissues while sparing healthy tissues remains a major challenge. The administration of exogenous target-specific triggers offers the potential for traceless release of active drugs… read more here.
Keywords: drug; platinum; bond cleavage; drug activation ... See more keywords
Self-boosting stimulus activation of a polyprodrug with cascade amplification for enhanced antitumor efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00647b
Abstract: The use of polyprodrugs, which bind drugs to polymer chains through responsive linkers, is a potential technique for cancer therapy; however, a lack of endogenous triggering factors limits drug activation in tumor tissue. Herein, we… read more here.
Keywords: drug activation; cascade amplification; polyprodrug; activation ... See more keywords