Drug Addiction and DNA Modifications.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-53889-1_6
Abstract: Drug addiction is a complex disorder which can be influenced by both genetic and environmental factors. Research has shown that epigenetic modifications can translate environmental signals into changes in gene expression, suggesting that epigenetic changes… read more here.
Keywords: addiction; drug; epigenetic changes; drug addiction ... See more keywords
Definition of Substance and Non-substance Addiction.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-5562-1_2
Abstract: Substance addiction (or drug addiction) is a neuropsychiatric disorder characterized by a recurring desire to continue taking the drug despite harmful consequences. Non-substance addiction (or behavioral addiction) covers pathological gambling, food addiction, internet addiction, and… read more here.
Keywords: addiction; substance; substance addiction; non substance ... See more keywords
The Role of DNA Methylation in Drug Addiction: Implications for Diagnostic and Therapeutics.
Sign Up to like & getrecommendations! Published in 2018 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2018.01.003
Abstract: Drug addiction is a devastating health problem that is a very heavy burden on the individual affected and the society in general. Recent research defines addiction as a neurobehavioral disorder. Underpinning biological mechanisms of drug… read more here.
Keywords: drug; dna methylation; addiction; drug addiction ... See more keywords
Effects of the hallucinogenic beverage ayahuasca on voluntary ethanol intake by rats and on cFos expression in brain areas relevant to drug addiction.
Sign Up to like & getrecommendations! Published in 2019 at "Alcohol"
DOI: 10.1016/j.alcohol.2019.10.005
Abstract: Ayahuasca is a hallucinogenic infusion used in religious ritualsthat has serotoninergic properties and may be a potential therapeutic option for drug addiction. In this study, Wistar rats had intermittent access to ethanol for 8 weeks,… read more here.
Keywords: ayahuasca; group; ethanol intake; cfos expression ... See more keywords
Characterization of locomotor response to psychostimulants in the parthenogenetic marbled crayfish (Procambarus fallax forma virginalis): A promising model for studying the neural and molecular mechanisms of drug addiction
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.12.024
Abstract: HIGHLIGHTSMarbled crayfish increase locomotion with initial psychostimulant exposure.Marbled crayfish display reduced locomotion with long‐term psychostimulant exposure.Drug‐infused water offers effective non‐invasive mode of drug delivery in crayfish. ABSTRACT Although scientific research using mammalian models has made… read more here.
Keywords: marbled crayfish; virginalis; drug; model ... See more keywords
Modeling drug addiction in females: how internal state and environmental context facilitate vulnerability
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Behavioral Sciences"
DOI: 10.1016/j.cobeha.2018.02.003
Abstract: A fundamental aspect of survival is the ability to refine behaviors based on internal and external contexts. Interpretation of rewarding stimuli is driven by integration of a diverse number of inputs including contextual cues, hormone… read more here.
Keywords: addiction; context; addiction females; vulnerability ... See more keywords
TIDAL: Topology-Inferred Drug Addiction Learning
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00046
Abstract: Drug addiction is a global public health crisis, and the design of antiaddiction drugs remains a major challenge due to intricate mechanisms. Since experimental drug screening and optimization are too time-consuming and expensive, there is… read more here.
Keywords: topology; topology inferred; inferred drug; drug addiction ... See more keywords
Near-Infrared Fluorescent Nanoprobes for Revealing the Role of Dopamine in Drug Addiction.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b12005
Abstract: Brain imaging techniques enable visualizing the activity of central nervous system without invasive neurosurgery. Dopamine is an important neurotransmitter. Its fluctuation in brain leads to a wide range of diseases and disorders, like drug addiction,… read more here.
Keywords: infrared fluorescent; near infrared; drug; brain ... See more keywords
Dopaminergic and glutamatergic biomarkers disruption in addiction and regulation by exercise: a mini review
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers"
DOI: 10.1080/1354750x.2022.2049367
Abstract: Abstract Introduction Drug addiction is associated with disruption of a multitude of biomarkers in various brain regions, particularly in the reward centre. The most pronounced are dopaminergic and glutamatergic biomarkers, which are affected at various… read more here.
Keywords: glutamatergic systems; glutamatergic biomarkers; drug addiction; dopaminergic glutamatergic ... See more keywords
The thalamus in drug addiction: from rodents to humans
Sign Up to like & getrecommendations! Published in 2018 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2017.0028
Abstract: Impairments in response inhibition and salience attribution (iRISA) have been proposed to underlie the clinical symptoms of drug addiction as mediated by cortico-striatal-thalamo-cortical networks. The bulk of evidence supporting the iRISA model comes from neuroimaging… read more here.
Keywords: addiction; thalamus drug; drug; response inhibition ... See more keywords
Reducing Craving and Consumption in Individuals with Drug Addiction, Obesity or Overeating through Neuromodulation Intervention: A Systematic Review and Meta-analysis of its Follow-up Effects.
Sign Up to like & getrecommendations! Published in 2021 at "Addiction"
DOI: 10.1111/add.15686
Abstract: BACKGROUND AND AIMS Non-invasive brain stimulation has shown potentials in clinical applications aiming at reducing craving and consumption levels in individuals with drug addiction or overeating behavior. However, it is unclear whether these intervention effects… read more here.
Keywords: intervention; craving consumption; consumption; drug addiction ... See more keywords