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Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200112
Abstract: Antibody-based therapeutic agents and other biopharmaceuticals are now used in the treatment of many diseases. However, when these biopharmaceuticals are administrated to patients, an immune reaction may occur that can reduce the drug's efficacy and…
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Keywords:
drug antibodies;
anti drug;
analysis;
detection analysis ... See more keywords
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Published in 2019 at "Clinical immunology"
DOI: 10.1016/j.clim.2019.01.009
Abstract: In Pompe disease, anti-drug antibodies (ADA) to acid alpha-glucosidase (GAA) enzyme replacement therapy contribute to early mortality. Assessing individual risk for ADA development is notoriously difficult in (CRIM-positive) patients expressing endogenous GAA. The individualized T…
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Keywords:
antibodies ada;
risk;
risk developing;
drug antibodies ... See more keywords
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1
Published in 2022 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2022.2114288
Abstract: Abstract Biologics may elicit the production of anti-drug antibodies (ADAs), the clinical significance of which is not fully understood. ADA development in psoriasis patients on IL-17 inhibitors was evaluated by incidence, impact on efficacy, and…
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Keywords:
ixekizumab brodalumab;
drug antibodies;
anti drug;
antibodies inhibitors ... See more keywords
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1
Published in 2020 at "British Journal of Dermatology"
DOI: 10.1111/bjd.18662
Abstract: Biologics are powerful drugs used to treat a range of diseases including psoriasis. They can be very effective; however, the body's immune system, which normally fights off infection, can produce ‘anti‐drug antibodies’ (or ADAs) that…
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Keywords:
develop anti;
drug antibodies;
drug;
many people ... See more keywords
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Published in 2022 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.18042
Abstract: Anti‐drug antibodies (ADAs) can form with certain biological medications, but their clinical significance is not fully understood. ADA formation in psoriasis patients treated with IL‐23 inhibitors was evaluated, looking at the incidence of ADAs, impact…
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Keywords:
neutralizing antibodies;
drug antibodies;
incidence;
anti drug ... See more keywords
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1
Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1016179
Abstract: The optimal use of many biotherapeutics is restricted by Anti-drug antibodies (ADAs) and hypersensitivity responses which can affect potency and ability to administer a treatment. Here we demonstrate that Re-surfacing can be utilized as a…
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Keywords:
hypersensitivity responses;
pre existing;
drug antibodies;
anti drug ... See more keywords
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1
Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1024963
Abstract: Enzyme replacement therapy (ERT) with recombinant α-galactosidase A (AGAL) can lead to the formation of neutralizing anti-drug antibodies (ADA), which significantly limit treatment efficacy in patients with Fabry disease (FD). The effects of dose escalation…
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Keywords:
dose escalation;
drug antibodies;
escalation;
anti drug ... See more keywords
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2
Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1105617
Abstract: Introduction Use of adeno-associated virus (AAV) vectors is complicated by host immune responses that can limit transgene expression. Recent clinical trials using AAV vectors to deliver HIV broadly neutralizing antibodies (bNAbs) by intramuscular administration resulted…
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Keywords:
drug antibodies;
anti drug;
expression;
aav vectors ... See more keywords
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Published in 2018 at "Antibodies"
DOI: 10.3390/antib7020019
Abstract: The development of anti-drug antibodies (ADAs) following administration of biotherapeutics to patients is a vexing problem that is attracting increasing attention from pharmaceutical and biotechnology companies. This serious clinical problem is also spawning creative research…
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Keywords:
immunogenicity;
approaches predict;
drug antibodies;
anti drug ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179561
Abstract: Background. Monitoring of biological TNF inhibitors is a very important tool to guide clinical decisions using specialized algorithms, especially in gastroenterology. A new chemiluminescent instrument (i-TRACK10® from Theradiag) could replace ELISA techniques to calculate the…
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Keywords:
drug antibodies;
anti drug;
random access;
new random ... See more keywords