Approaches for the detection and analysis of anti-drug antibodies to biopharmaceuticals: A review.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202200112
Abstract: Antibody-based therapeutic agents and other biopharmaceuticals are now used in the treatment of many diseases. However, when these biopharmaceuticals are administrated to patients, an immune reaction may occur that can reduce the drug's efficacy and… read more here.
Keywords: drug antibodies; anti drug; analysis; detection analysis ... See more keywords
Interplay between pharmacokinetics and immunogenicity of therapeutic proteins: stepwise development of a bidirectional joint pharmacokinetics-anti-drug antibodies model
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Pharmacokinetics and Pharmacodynamics"
DOI: 10.1007/s10928-025-09971-w
Abstract: The aim of the analysis was to develop a phenomenological longitudinal population pharmacokinetics (PK)-anti-drug antibodies (ADA) model to enable an informed and quantitative framework for assessment of ADA influence. Data used were from seven clinical… read more here.
Keywords: time; drug antibodies; anti drug; drug ... See more keywords
HLA- and genotype-based risk assessment model to identify infantile onset pompe disease patients at high-risk of developing significant anti-drug antibodies (ADA).
Sign Up to like & getrecommendations! Published in 2019 at "Clinical immunology"
DOI: 10.1016/j.clim.2019.01.009
Abstract: In Pompe disease, anti-drug antibodies (ADA) to acid alpha-glucosidase (GAA) enzyme replacement therapy contribute to early mortality. Assessing individual risk for ADA development is notoriously difficult in (CRIM-positive) patients expressing endogenous GAA. The individualized T… read more here.
Keywords: antibodies ada; risk; risk developing; drug antibodies ... See more keywords
Anti-drug antibodies of IL-17 inhibitors for psoriasis: a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2022.2114288
Abstract: Abstract Biologics may elicit the production of anti-drug antibodies (ADAs), the clinical significance of which is not fully understood. ADA development in psoriasis patients on IL-17 inhibitors was evaluated by incidence, impact on efficacy, and… read more here.
Keywords: ixekizumab brodalumab; drug antibodies; anti drug; antibodies inhibitors ... See more keywords
Interference from anti-drug antibodies on the quantification of insulin: a comparison of an LC-MS/MS assay and immunoassays
Sign Up to like & getrecommendations! Published in 2024 at "Bioanalysis"
DOI: 10.1080/17576180.2024.2389637
Abstract: Aim: This study aims to compare the anti-drug antibody (ADA) interference in four pharmacokinetic (PK) assays across different platforms (AlphaLISA, Gyrolab, LC-MS/MS) and to devise a strategy for ADA interference mitigation to improve the accuracy… read more here.
Keywords: insulin; drug antibodies; anti drug; drug ... See more keywords
Simultaneous isotyping and semi-quantitation of anti-drug antibodies to an IgG1 biotherapeutic using hybrid LBA-LC-MS/MS.
Sign Up to like & getrecommendations! Published in 2024 at "Bioanalysis"
DOI: 10.1080/17576180.2024.2441058
Abstract: BACKGROUND Commonly, ligand-binding platforms are being used for immunogenicity assessment, but with the recent advent of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for protein quantification, this technology has become an alternative for the… read more here.
Keywords: isotyping semi; drug antibodies; anti drug; drug ... See more keywords
Heterogeneous and evolving epitope landscape of clinical anti-drug antibodies against multidomain biotherapeutic: a case study of TAK-186
Sign Up to like & getrecommendations! Published in 2025 at "mAbs"
DOI: 10.1080/19420862.2025.2587584
Abstract: ABSTRACT The emergence of anti-drug antibodies (ADAs) poses a major obstacle in the clinical development of therapeutic proteins (TPs) such as monoclonal antibodies and their derivatives. While standard multitiered ADA assays and neutralizing antibody assays… read more here.
Keywords: drug antibodies; anti drug; case study; ada epitope ... See more keywords
P468 Relevance of anti-drug antibodies in context of supra-therapeutic anti-TNF concentrations
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjad212.0598
Abstract: The low serum concentration of anti-tumor necrosis factor-alpha (anti-TNFα) agents and the presence of anti-drug antibodies are related to poor therapeutic outcomes in inflammatory bowel disease (IBD). We aimed to evaluate the prognosis of patients… read more here.
Keywords: drug antibodies; anti drug; antidrug antibodies; drug ... See more keywords
How many people develop anti‐drug antibodies to the biologic drug tildrakizumab, and what impact does this have on the effectiveness of their treatment
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Dermatology"
DOI: 10.1111/bjd.18662
Abstract: Biologics are powerful drugs used to treat a range of diseases including psoriasis. They can be very effective; however, the body's immune system, which normally fights off infection, can produce ‘anti‐drug antibodies’ (or ADAs) that… read more here.
Keywords: develop anti; drug antibodies; drug; many people ... See more keywords
Anti‐drug antibodies of IL‐23 inhibitors for psoriasis: a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.18042
Abstract: Anti‐drug antibodies (ADAs) can form with certain biological medications, but their clinical significance is not fully understood. ADA formation in psoriasis patients treated with IL‐23 inhibitors was evaluated, looking at the incidence of ADAs, impact… read more here.
Keywords: neutralizing antibodies; drug antibodies; incidence; anti drug ... See more keywords
Protein re-surfacing of E. coli L-Asparaginase to evade pre-existing anti-drug antibodies and hypersensitivity responses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1016179
Abstract: The optimal use of many biotherapeutics is restricted by Anti-drug antibodies (ADAs) and hypersensitivity responses which can affect potency and ability to administer a treatment. Here we demonstrate that Re-surfacing can be utilized as a… read more here.
Keywords: hypersensitivity responses; pre existing; drug antibodies; anti drug ... See more keywords