The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice.
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DOI: 10.2139/ssrn.3929011
Abstract: Low-grade, sustained inflammation in white adipose tissue (WAT) characterizes obesity and coincides with type 2 diabetes mellitus (T2DM). However, pharmacological targeting of inflammation lacks durable therapeutic effects in insulin-resistant conditions. Through a computational screen, we… read more here.
Keywords: drug auranofin; leptin levels; rheumatoid arthritis; antidiabetic effects ... See more keywords